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    ces2b carboxylesterase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 561967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ces2bprovided by ZNC
    Official Full Name
    carboxylesterase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041014-96
    See related
    AllianceGenome:ZFIN:ZDB-GENE-041014-96
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb62a02; si:ch211-93f2.1
    Summary
    Enables cholinesterase activity. Is expressed in gut; intestinal bulb; and liver. Orthologous to several human genes including CES1P1 (carboxylesterase 1 pseudogene 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ces2b in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (30362898..30429621, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (29919796..29986629, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene TopBP1-interacting, checkpoint, and replication regulator Neighboring gene protein disulfide isomerase family A, member 3 Neighboring gene transfer RNA arginine (anticodon ACG) Neighboring gene transfer RNA arginine (anticodon ACG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of an atypical butyrylcholinesterase-like protein in zebrafish. Tan KS, et al. Comp Biochem Physiol B Biochem Mol Biol, 2021 Aug-Sep. PMID 33662568
    2. Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae. Howarth DL, et al. Zebrafish, 2013 Jun. PMID 23697887, Free PMC Article
    3. Crosstalk of oxidative damage, apoptosis, and autophagy under endoplasmic reticulum (ER) stress involved in thifluzamide-induced liver damage in zebrafish (Danio rerio). Yang Y, et al. Environ Pollut, 2018 Dec. PMID 30408879
    4. Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Passeri MJ, et al. Hepatology, 2009 Feb. PMID 19127516, Free PMC Article
    5. Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish. Cinaroglu A, et al. Hepatology, 2011 Aug. PMID 21538441, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cholinesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carboxylesterase 2b; uncharacterized protein ces2b
    Names
    novel carboxylesterase domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      30362898..30429621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470705.2 → XP_021326380.1  uncharacterized protein ces2b

      UniProtKB/TrEMBL
      A0A8M9PZ17
      Conserved Domains (1) summary
      pfam00135
      Location:27 → 539
      COesterase; Carboxylesterase family
    Nucleotide Protein Strain
    Heading Accession and Version

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