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    pdcd4a programmed cell death 4a [ Danio rerio (zebrafish) ]

    Gene ID: 406261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pdcd4aprovided by ZNC
    Official Full Name
    programmed cell death 4aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1920
    See related
    Ensembl:ENSDARG00000021702 AllianceGenome:ZFIN:ZDB-GENE-040426-1920
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66311; wu:fa55g03; wu:fb08a11; wu:fe01a02
    Summary
    Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including head; immature eye; midbrain; neural plate; and segmental plate. Orthologous to human PDCD4 (programmed cell death 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pdcd4a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (26046146..26063181, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (25352432..25369479, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495493 Neighboring gene G patch domain and ankyrin repeats 1 Neighboring gene MAX dimerization protein 4 Neighboring gene NADH:ubiquinone oxidoreductase subunit B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21. Banjo T, et al. Nat Commun, 2013. PMID 23748970, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    programmed cell death protein 4a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212988.1 → NP_998153.1  programmed cell death protein 4a

      See identical proteins and their annotated locations for NP_998153.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054680
      UniProtKB/TrEMBL
      Q7SYL0
      Related
      ENSDARP00000148546.1, ENSDART00000185348.1
      Conserved Domains (1) summary
      smart00544
      Location:328 → 431
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      26046146..26063181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159885.5 → XP_005159942.1  programmed cell death protein 4a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B6S0, F1QBM2
      Related
      ENSDARP00000131636.1, ENSDART00000168640.2
      Conserved Domains (1) summary
      smart00544
      Location:328 → 431
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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