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    tia1 TIA1 cytotoxic granule-associated RNA binding protein [ Danio rerio (zebrafish) ]

    Gene ID: 793165, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tia1provided by ZNC
    Official Full Name
    TIA1 cytotoxic granule-associated RNA binding proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1506
    See related
    Ensembl:ENSDARG00000052536 AllianceGenome:ZFIN:ZDB-GENE-030131-1506
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb73d10; zgc:55520; wu:fb73d10; wu:fc02b04
    Summary
    Enables mRNA 3'-UTR binding activity. Is expressed in brain; retina; retinal ganglion cell layer; retinal inner nuclear layer; and trunk. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tia1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (56950861..56964509, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (56280644..56294330, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1Db Neighboring gene si:ch211-127d4.3 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene transmembrane protein 232

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of cellular protein expression profiles in response to grass carp reovirus infection. Xu D, et al. Fish Shellfish Immunol, 2015 Jun. PMID 25783000
    2. Amyloid-like Self-Assembly of a Cellular Compartment. Boke E, et al. Cell, 2016 Jul 28. PMID 27471966, Free PMC Article
    3. The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Shankar P, et al. Toxicol Sci, 2022 May 26. PMID 35377459, Free PMC Article
    4. ALS-associated genes display CNS expression in the developing zebrafish. Laboissonniere LA, et al. Gene Expr Patterns, 2018 Dec. PMID 30165106
    5. Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Vejnar CE, et al. Genome Res, 2019 Jul. PMID 31227602, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55520

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    cytotoxic granule associated RNA binding protein TIA1
    Names
    cytotoxic granule-associated RNA binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212628.1 → NP_997793.1  cytotoxic granule associated RNA binding protein TIA1

      See identical proteins and their annotated locations for NP_997793.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045368
      UniProtKB/TrEMBL
      A0A8N7V096, A2ATY3, Q7ZVY0
      Related
      ENSDARP00000068889.4, ENSDART00000074400.5
      Conserved Domains (4) summary
      cd12615
      Location:9 → 82
      RRM1_TIA1; RNA recognition motif 1 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12618
      Location:95 → 174
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12621
      Location:204 → 277
      RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      TIGR01661
      Location:6 → 270
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      56950861..56964509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301867.3 → XP_009300142.1  cytotoxic granule associated RNA binding protein TIA1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AZZ3
      Conserved Domains (4) summary
      cd12615
      Location:9 → 82
      RRM1_TIA1; RNA recognition motif 1 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12618
      Location:95 → 174
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12621
      Location:204 → 277
      RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      TIGR01661
      Location:6 → 270
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394615.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      305757..310746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395246.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      201190..206179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_3

    Genomic

    1. NW_018395376.1 Reference GRCz11 ALT_DRER_TU_3

      Range
      220084..232691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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