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    smyhc1 slow myosin heavy chain 1 [ Danio rerio (zebrafish) ]

    Gene ID: 321552, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smyhc1provided by ZNC
    Official Full Name
    slow myosin heavy chain 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-271
    See related
    Ensembl:ENSDARG00000099959 AllianceGenome:ZFIN:ZDB-GENE-030131-271
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb18g10; im:6897999; wu:fb18g10
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within several processes, including regulation of myofibril size; slow-twitch skeletal muscle fiber contraction; and striated muscle cell development. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in cardiovascular system; musculature system; paraxial mesoderm; and somite. Used to study distal arthrogryposis and spondylocarpotarsal synostosis syndrome. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See smyhc1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (40656508..40668217, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (40956286..40968477, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 2b Neighboring gene microtubule-associated protein 4 Neighboring gene uncharacterized LOC110439132 Neighboring gene slow myosin heavy chain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite. Abe K, et al. Cell Rep, 2019 Apr 16. PMID 30995487
    2. Temporal and spatial requirements of unplugged/MuSK function during zebrafish neuromuscular development. Jing L, et al. PLoS One, 2010 Jan 22. PMID 20107509, Free PMC Article
    3. Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons. Nemoz-Billet L, et al. Proc Natl Acad Sci U S A, 2024 Mar 26. PMID 38502691, Free PMC Article
    4. Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation. Hau HA, et al. Dev Biol, 2023 Jul. PMID 37121308, Free PMC Article
    5. Myosin heavy chain expression in zebrafish and slow muscle composition. Bryson-Richardson RJ, et al. Dev Dyn, 2005 Jul. PMID 15830374

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation.
      Title: Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation.
    2. studies indicate that Smyhc1 is essential for myogenesis in embryonic slow muscles, and loss of Smyhc1 results in defective sarcomere assembly, reduces larval motility and fish survival, but has no visible impact on muscle growth in juvenile and adult zebrafish that escape the larval lethality.
      Title: Defective sarcomere organization and reduced larval locomotion and fish survival in slow muscle heavy chain 1 (smyhc1) mutants.
    3. Studies indicate that myosin thick filaments are required for M-line organization and M-line localization of myomesin-3. In contrast, myomesin-3 is dispensable for sarcomere organization in slow muscles.
      Title: Functional analysis of slow myosin heavy chain 1 and myomesin-3 in sarcomere organization in zebrafish embryonic slow muscles.
    4. studies indicate that the hsp90alpha1 mutant phenotype is not simply due to disruption of myosin folding and assembly, suggesting that Hsp90alpha1 may play a role in the assembly and organization of other sarcomeric structures
      Title: Loss of Smyhc1 or Hsp90alpha1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryos.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle filament sliding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within notochord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of myofibril size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle thin filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within slow-twitch skeletal muscle fiber contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within striated muscle myosin thick filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    slow myosin heavy chain 1
    Names
    smhc1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020507.1 → NP_001018343.1  slow myosin heavy chain 1

      See identical proteins and their annotated locations for NP_001018343.1

      Status: PROVISIONAL

      Source sequence(s)
      AY921649
      UniProtKB/TrEMBL
      Q508P8
      Related
      ENSDARP00000135954.1, ENSDART00000169315.2
      Conserved Domains (7) summary
      cd01377
      Location:99 → 768
      MYSc_class_II; class II myosins, motor domain
      pfam00063
      Location:87 → 768
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:848 → 1925
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:35 → 72
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1457 → 1562
      TMPIT; TMPIT-like protein
      cl19764
      Location:1374 → 1507
      COG6; Conserved oligomeric complex COG6
      cl23720
      Location:963 → 1096
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      40656508..40668217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162920.5 → XP_005162977.1  slow myosin heavy chain 1 isoform X1

      UniProtKB/TrEMBL
      A0A0R4INI3, A0A0R4IVW7, A0A8M2B9W6
      Related
      ENSDARP00000139007.2, ENSDART00000171543.2
      Conserved Domains (7) summary
      cd01377
      Location:99 → 768
      MYSc_class_II; class II myosins, motor domain
      pfam00063
      Location:87 → 768
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:848 → 1925
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:35 → 72
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1457 → 1562
      TMPIT; TMPIT-like protein
      cl19764
      Location:1374 → 1507
      COG6; Conserved oligomeric complex COG6
      cl23720
      Location:963 → 1096
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395185.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      92557..103849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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