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    axin2 axin 2 (conductin, axil) [ Danio rerio (zebrafish) ]

    Gene ID: 58080, updated on 5-Jan-2025

    Summary

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    Official Symbol
    axin2provided by ZNC
    Official Full Name
    axin 2 (conductin, axil)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000403-2
    See related
    Ensembl:ENSDARG00000100149 AllianceGenome:ZFIN:ZDB-GENE-000403-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    axil; wu:fb37c08; zgc:111942
    Summary
    Predicted to enable several functions, including I-SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in negative regulation of canonical Wnt signaling pathway. Acts upstream of or within dorsal/ventral axis specification and heart development. Predicted to be located in cytoplasm. Predicted to be part of beta-catenin destruction complex. Predicted to be active in nucleus and plasma membrane. Is expressed in several structures, including anterior neural keel; marginal blastomere; nervous system; pharyngeal arch; and pleuroperitoneal region. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in endometrial adenocarcinoma; gastrointestinal system cancer (multiple); lung cancer (multiple); and orofacial cleft. Orthologous to human AXIN2 (axin 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See axin2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (55631128..55650725, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (55379519..55399116, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA50 Neighboring gene testis expressed 2 Neighboring gene centrosomal protein 112 Neighboring gene protein kinase C, alpha, b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Midbrain tectal stem cells display diverse regenerative capacities in zebrafish. Lindsey BW, et al. Sci Rep, 2019 Mar 14. PMID 30872640, Free PMC Article
    2. Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia. Haramis AP, et al. EMBO Rep, 2006 Apr. PMID 16439994, Free PMC Article
    3. Novel mutations of AXIN2 identified in a Chinese Congenital Heart Disease Cohort. Zhu MJ, et al. J Hum Genet, 2019 May. PMID 30760879
    4. Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins. Kang J, et al. Dev Cell, 2013 Oct 14. PMID 24135229, Free PMC Article
    5. Nkd1 functions downstream of Axin2 to attenuate Wnt signaling. Bell I, et al. Mol Biol Cell, 2024 Jul 1. PMID 38656801, Free PMC Article

    See all (189) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nkd1 functions downstream of Axin2 to attenuate Wnt signaling.
      Title: Nkd1 functions downstream of Axin2 to attenuate Wnt signaling.
    2. Activation of WNT signaling restores the facial deficits in a zebrafish with defects in cholesterol metabolism.
      Title: Activation of WNT signaling restores the facial deficits in a zebrafish with defects in cholesterol metabolism.
    3. beta-catenin1 cannot revert the ich phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS domain function.
      Title: The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables I-SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral axis specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IDA
    Inferred from Direct Assay
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of centromeric sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of beta-catenin destruction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    axin-2
    Names
    axis inhibition protein 2
    etID37069.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131561.1 → NP_571636.1  axin-2

      See identical proteins and their annotated locations for NP_571636.1

      Status: PROVISIONAL

      Source sequence(s)
      AB032263
      UniProtKB/Swiss-Prot
      P57095, Q335M5
      Related
      ENSDARP00000132477.1, ENSDART00000162413.2
      Conserved Domains (4) summary
      cd08707
      Location:85 → 201
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      pfam00778
      Location:732 → 807
      DIX; DIX domain
      pfam08833
      Location:429 → 464
      Axin_b-cat_bind; Axin beta-catenin binding domain
      pfam16646
      Location:5 → 76
      AXIN1_TNKS_BD; Axin-1 tankyrase binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      55631128..55650725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57095.1 GenPept UniProtKB/Swiss-Prot:P57095

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.