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    kyat1 kynurenine aminotransferase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 791592, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kyat1provided by ZNC
    Official Full Name
    kynurenine aminotransferase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2676
    See related
    Ensembl:ENSDARG00000023645 AllianceGenome:ZFIN:ZDB-GENE-040426-2676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ccbl1; zgc:63644
    Summary
    Predicted to enable kynurenine-oxoglutarate transaminase activity. Predicted to act upstream of or within biosynthetic process. Predicted to be active in mitochondrion. Is expressed in intestinal bulb; pronephric duct; and pronephros. Orthologous to human KYAT1 (kynurenine aminotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kyat1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (33266405..33274983, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (32666253..32674915, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene protein kinase, AMP-activated, alpha 1 catalytic subunit Neighboring gene interferon induced transmembrane protein 1 Neighboring gene surfeit 6 Neighboring gene SURF1 cytochrome c oxidase assembly factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Hensley MR, et al. Sci Rep, 2016 Jun 13. PMID 27292017, Free PMC Article
    2. Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development. Tallafuss A, et al. Gene Expr Patterns, 2006 Jun. PMID 16448862
    3. Positive correlation between gene coexpression and positional clustering in the zebrafish genome. Ng YK, et al. BMC Genomics, 2009 Jan 22. PMID 19159490, Free PMC Article
    4. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Baraban SC, et al. Nat Commun, 2013. PMID 24002024, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63644

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kynurenine-oxoglutarate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kynurenine--oxoglutarate transaminase 1
    Names
    cysteine conjugate-beta lyase, cytoplasmic
    glutamine transaminase K, kyneurenine aminotransferase
    NP_998524.2
    XP_005171979.1
    XP_005171980.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213359.2 → NP_998524.2  kynurenine--oxoglutarate transaminase 1

      Status: VALIDATED

      Source sequence(s)
      CU019641, DT059481, EH538028
      UniProtKB/TrEMBL
      A0A8M1PF14, F1QAI8
      Related
      ENSDARP00000019368.8, ENSDART00000004797.10
      Conserved Domains (2) summary
      cd00609
      Location:57 → 441
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK08912
      Location:43 → 442
      PRK08912; hypothetical protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      33266405..33274983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171923.5 → XP_005171980.1  kynurenine--oxoglutarate transaminase 1 isoform X1

      See identical proteins and their annotated locations for XP_005171980.1

      UniProtKB/TrEMBL
      A0A8M1PF14, F1QAI8
      Related
      ENSDARP00000148599.1, ENSDART00000188584.1
      Conserved Domains (2) summary
      cd00609
      Location:57 → 441
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK08912
      Location:43 → 442
      PRK08912; hypothetical protein; Provisional

    2. XM_005171922.5 → XP_005171979.1  kynurenine--oxoglutarate transaminase 1 isoform X1

      See identical proteins and their annotated locations for XP_005171979.1

      UniProtKB/TrEMBL
      A0A8M1PF14, F1QAI8
      Conserved Domains (2) summary
      cd00609
      Location:57 → 441
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK08912
      Location:43 → 442
      PRK08912; hypothetical protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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