U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    wipi2 WD repeat domain, phosphoinositide interacting 2 [ Danio rerio (zebrafish) ]

    Gene ID: 437002, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    wipi2provided by ZNC
    Official Full Name
    WD repeat domain, phosphoinositide interacting 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-488
    See related
    Ensembl:ENSDARG00000037871 AllianceGenome:ZFIN:ZDB-GENE-040718-488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92576
    Summary
    Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagy of mitochondrion and macroautophagy. Predicted to act upstream of or within autophagy. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WIPI2 (WD repeat domain, phosphoinositide interacting 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See wipi2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (40820614..40837383, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (40678756..40695525, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex, subunit 1A Neighboring gene actin related protein 2/3 complex, subunit 1B Neighboring gene monocyte to macrophage differentiation-associated 2a Neighboring gene adaptor related protein complex 5 subunit zeta 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex. Meireles AM, et al. Dev Cell, 2018 Nov 5. PMID 30399334, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    WD repeat domain phosphoinositide-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327789.1 → NP_001314718.1  WD repeat domain phosphoinositide-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      BX649536
      UniProtKB/TrEMBL
      A0A8M1P910
      Conserved Domains (3) summary
      COG2319
      Location:21 → 261
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:58 → 99
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:121 → 267
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      40820614..40837383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164125.5 → XP_005164182.1  WD repeat domain phosphoinositide-interacting protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BBE9, F1QLJ9
      Related
      ENSDARP00000118552.1, ENSDART00000134026.3
      Conserved Domains (3) summary
      COG2319
      Location:21 → 272
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:58 → 99
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:121 → 265
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002729.1: Suppressed sequence

      Description
      NM_001002729.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools