U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    prph peripherin [ Danio rerio (zebrafish) ]

    Gene ID: 30259, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    prphprovided by ZNC
    Official Full Name
    peripherinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-207
    See related
    Ensembl:ENSDARG00000028306 AllianceGenome:ZFIN:ZDB-GENE-990415-207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    plasticin; zgc:111926
    Summary
    Predicted to enable structural molecule activity. Acts upstream of or within tissue regeneration. Predicted to be located in intermediate filament. Predicted to be active in axon; plasma membrane; and type III intermediate filament. Is expressed in nervous system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 1. Orthologous to human PRPH (peripherin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See prph in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (3320598..3334248, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (3252438..3266088, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 2 Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene tubulin, alpha 2 Neighboring gene sulfite oxidase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Gefiltin in zebrafish embryos: sequential gene expression of two neurofilament proteins in retinal ganglion cells. Leake D, et al. Differentiation, 1999 Dec. PMID 10653354
    2. Developmental pattern of the neuronal intermediate filament inaa in the zebrafish retina. Liao ML, et al. J Comp Neurol, 2016 Dec 15. PMID 27159642
    3. Gene expression profiles of intact and regenerating zebrafish retina. Cameron DA, et al. Mol Vis, 2005 Sep 20. PMID 16205622
    4. The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation. Wheeler NA, et al. J Neurosci, 2015 Aug 12. PMID 26269646, Free PMC Article
    5. FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition. Goto H, et al. Development, 2017 Apr 15. PMID 28242612, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in type III intermediate filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    peripherin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319237.1 → NP_001306166.1  peripherin

      Status: VALIDATED

      Source sequence(s)
      CU633810, FO704600
      UniProtKB/TrEMBL
      A0A8M1P836, Q502Q7
      Related
      ENSDARP00000129087.1, ENSDART00000154314.3
      Conserved Domains (3) summary
      pfam00038
      Location:72 → 385
      Filament; Intermediate filament protein
      pfam04732
      Location:1 → 71
      Filament_head; Intermediate filament head (DNA binding) region
      cl12013
      Location:178 → 352
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      3320598..3334248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_131054.1: Suppressed sequence

      Description
      NM_131054.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools