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    kpna6 karyopherin alpha 6 (importin alpha 7) [ Danio rerio (zebrafish) ]

    Gene ID: 100149852, updated on 27-Dec-2024

    Summary

    Official Symbol
    kpna6provided by ZNC
    Official Full Name
    karyopherin alpha 6 (importin alpha 7)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-130530-626
    See related
    Ensembl:ENSDARG00000044980 AllianceGenome:ZFIN:ZDB-GENE-130530-626
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Orthologous to human KPNA6 (karyopherin subunit alpha 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See kpna6 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (29861854..29887644, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (30278405..30300384, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:ch73-130a3.4 Neighboring gene taxilin alpha Neighboring gene uncharacterized LOC137488528 Neighboring gene KH domain containing, RNA binding, signal transduction associated 1b Neighboring gene tetraspanin 13b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    importin subunit alpha-7
    Names
    zmp:0000000623

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      29861854..29887644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001923886.7XP_001923921.1  importin subunit alpha-7

      UniProtKB/TrEMBL
      A0A8M1QRD2, E7F7U9
      Related
      ENSDARP00000066122.5, ENSDART00000066123.7
      Conserved Domains (5) summary
      COG5064
      Location:36536
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:252366
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:9103
      IBB; Importin beta binding domain
      pfam16186
      Location:465511
      Arm_3; Atypical Arm repeat
      sd00043
      Location:255280
      ARM; armadillo repeat [structural motif]