prkcbp1l protein kinase C binding protein 1, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prkcbp1lprovided by ZNC
Official Full Name: protein kinase C binding protein 1, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2199
See related: Ensembl:ENSDARG00000011932 AllianceGenome:ZFIN:ZDB-GENE-030131-2199
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63775; im:7138336; wu:fb99d12
Summary: Predicted to enable transcription corepressor activity. Predicted to act upstream of or within phosphorylation and regulation of DNA-templated transcription. Predicted to be active in cytoplasm and nucleus. Orthologous to human ZMYND8 (zinc finger MYND-type containing 8). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (9809634..9897957, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (9874664..9930883, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein kinase C binding protein 1, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199641.2 → NP_955935.2 protein kinase C binding protein 1, like

Status: VALIDATED

Source sequence(s)

BX324190

UniProtKB/TrEMBL

A0A8M2B8U2, F1QYK7, Q6PEH2

Related

ENSDARP00000105974.1, ENSDART00000124510.4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

9809634..9897957 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068216680.1 → XP_068072781.1 protein kinase C binding protein 1, like isoform X2

UniProtKB/TrEMBL

A0A8M2B8R7, F1RDH9, Q6PEH2
XM_005161946.5 → XP_005162003.1 protein kinase C binding protein 1, like isoform X3

UniProtKB/TrEMBL

A0A8M2B8Q6, Q6PEH2

Conserved Domains (6) summary

cd05841
Location:263 → 343

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:145 → 243

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:84 → 124

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1009 → 1043

zf-MYND; MYND finger

pfam07798
Location:914 → 1005

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:420 → 601

DUF3544; Domain of unknown function (DUF3544)
XM_009296664.4 → XP_009294939.1 protein kinase C binding protein 1, like isoform X4

UniProtKB/TrEMBL

A0A8M3AMN3, Q6PEH2

Conserved Domains (6) summary

cd05841
Location:261 → 341

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:143 → 241

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:82 → 122

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1007 → 1041

zf-MYND; MYND finger

pfam07798
Location:912 → 1003

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:418 → 599

DUF3544; Domain of unknown function (DUF3544)
XM_009296662.4 → XP_009294937.1 protein kinase C binding protein 1, like isoform X1

UniProtKB/TrEMBL

A0A8M3AV41, Q6PEH2

Conserved Domains (6) summary

cd05841
Location:287 → 367

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:169 → 267

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:108 → 148

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1033 → 1067

zf-MYND; MYND finger

pfam07798
Location:938 → 1029

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:444 → 625

DUF3544; Domain of unknown function (DUF3544)
XM_005161945.5 → XP_005162002.1 protein kinase C binding protein 1, like isoform X2

See identical proteins and their annotated locations for XP_005162002.1

UniProtKB/TrEMBL

A0A8M2B8R7, F1RDH9, Q6PEH2

Related

ENSDARP00000157544.1, ENSDART00000180159.1

Conserved Domains (6) summary

cd05841
Location:269 → 349

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:151 → 249

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:90 → 130

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1015 → 1049

zf-MYND; MYND finger

pfam07798
Location:920 → 1011

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:426 → 607

DUF3544; Domain of unknown function (DUF3544)
XM_005161944.5 → XP_005162001.1 protein kinase C binding protein 1, like isoform X2

See identical proteins and their annotated locations for XP_005162001.1

UniProtKB/TrEMBL

A0A8M2B8R7, F1RDH9, Q6PEH2

Related

ENSDARP00000025195.8, ENSDART00000005015.10

Conserved Domains (6) summary

cd05841
Location:269 → 349

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:151 → 249

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:90 → 130

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1015 → 1049

zf-MYND; MYND finger

pfam07798
Location:920 → 1011

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:426 → 607

DUF3544; Domain of unknown function (DUF3544)