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    slc6a1b solute carrier family 6 member 1b [ Danio rerio (zebrafish) ]

    Gene ID: 492490, updated on 9-Dec-2024

    Summary

    Official Symbol
    slc6a1bprovided by ZNC
    Official Full Name
    solute carrier family 6 member 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-57
    See related
    Ensembl:ENSDARG00000039647 AllianceGenome:ZFIN:ZDB-GENE-041114-57
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    slc6a1; wu:fj45h10; wu:fq41d04; zgc:103663
    Summary
    Predicted to enable gamma-aminobutyric acid:sodium:chloride symporter activity. Predicted to be involved in amino acid transport and sodium ion transmembrane transport. Predicted to act upstream of or within neurotransmitter transport. Predicted to be located in membrane. Predicted to be active in axon; cell surface; and plasma membrane. Is expressed in basal plate midbrain region and nervous system. Human ortholog(s) of this gene implicated in alcohol dependence and myoclonic-atonic epilepsy. Orthologous to human SLC6A1 (solute carrier family 6 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See slc6a1b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (998789..1024483, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (972201..997895, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene ATG7 autophagy related 7 homolog (S. cerevisiae) Neighboring gene histamine receptor H1 Neighboring gene uncharacterized LOC100003140 Neighboring gene uncharacterized LOC137496749 Neighboring gene solute carrier family 6 member 11b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables gamma-aminobutyric acid:sodium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables gamma-aminobutyric acid:sodium:chloride symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sodium- and chloride-dependent GABA transporter 1b
    Names
    gat-1
    solute carrier family 6 (neurotransmitter transporter), member 1b
    solute carrier family 6 (neurotransmitter transporter, GABA), member 1
    solute carrier family 6 (neurotransmitter transporter, GABA), member 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007362.1NP_001007363.1  sodium- and chloride-dependent GABA transporter 1b

      See identical proteins and their annotated locations for NP_001007363.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085579
      UniProtKB/TrEMBL
      A0A8M1N394, Q5U3E5
      Related
      ENSDARP00000005281.8, ENSDART00000017551.11
      Conserved Domains (1) summary
      cl00456
      Location:2600
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      998789..1024483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)