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    ubqln4 ubiquilin 4 [ Danio rerio (zebrafish) ]

    Gene ID: 334337, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ubqln4provided by ZNC
    Official Full Name
    ubiquilin 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6269
    See related
    Ensembl:ENSDARG00000052975 AllianceGenome:ZFIN:ZDB-GENE-030131-6269
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ubin; zgc:66188; wu:fb48e11; wu:fb54b10; wu:fi41e06; zgc:113928
    Summary
    Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Is expressed in muscle and trunk. Orthologous to human UBQLN4 (ubiquilin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ubqln4 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (46666175..46681170)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (46699459..46714454)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 176l.2 Neighboring gene transmembrane protein 176l.4 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene RAB25, member RAS oncogene family b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mechanism of toxic effects of Nano-ZnO on cell cycle of zebrafish (Danio rerio). Hou J, et al. Chemosphere, 2019 Aug. PMID 31078877
    2. ALS-associated genes display CNS expression in the developing zebrafish. Laboissonniere LA, et al. Gene Expr Patterns, 2018 Dec. PMID 30165106
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113928

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquilin-4
    Names
    ataxin-1 ubiquitin-like interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213356.2 → NP_998521.2  ubiquilin-4

      See identical proteins and their annotated locations for NP_998521.2

      Status: PROVISIONAL

      Source sequence(s)
      BC098879
      UniProtKB/TrEMBL
      Q4G000
      Related
      ENSDARP00000069405.3, ENSDART00000074919.5
      Conserved Domains (4) summary
      smart00727
      Location:186 → 223
      STI1; Heat shock chaperonin-binding motif
      cd01808
      Location:26 → 96
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      smart00213
      Location:26 → 96
      UBQ; Ubiquitin homologues
      cd14399
      Location:556 → 595
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      46666175..46681170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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