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    itm2bb integral membrane protein 2Bb [ Danio rerio (zebrafish) ]

    Gene ID: 406248, updated on 9-Dec-2024

    Summary

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    Official Symbol
    itm2bbprovided by ZNC
    Official Full Name
    integral membrane protein 2Bbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2139
    See related
    Ensembl:ENSDARG00000041505 AllianceGenome:ZFIN:ZDB-GENE-040426-2139
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    itm2bl; fb94b03; zgc:64142; wu:fb94b03
    Summary
    Predicted to enable amyloid-beta binding activity. Predicted to be involved in negative regulation of amyloid precursor protein biosynthetic process. Predicted to be located in Golgi membrane and endosome membrane. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in blood; macrophage; pronephric duct; ventral mesenchyme; and yolk syncytial layer. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See itm2bb in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (25330932..25346583)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (25520063..25535714)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a Neighboring gene mediator complex subunit 4 Neighboring gene enhancer of polycomb homolog 2 (Drosophila) Neighboring gene activin A receptor type 2Aa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Li RF, et al. Biomedicines, 2022 May 27. PMID 35740282, Free PMC Article
    2. Identification of p53-target genes in Danio rerio. Mandriani B, et al. Sci Rep, 2016 Sep 1. PMID 27581768, Free PMC Article
    3. Hepatic gene expression profiling using GeneChips in zebrafish exposed to 17alpha-methyldihydrotestosterone. Hoffmann JL, et al. Aquat Toxicol, 2008 Apr 28. PMID 18339436
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of amyloid precursor protein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    integral membrane protein 2Bb
    Names
    integral membrane protein 2B, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212976.1 → NP_998141.1  integral membrane protein 2Bb

      See identical proteins and their annotated locations for NP_998141.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053278
      UniProtKB/TrEMBL
      A0A8M1PIE5, Q7T328
      Related
      ENSDARP00000092244.3, ENSDART00000101470.5
      Conserved Domains (1) summary
      smart01039
      Location:124 → 218
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      25330932..25346583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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