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    txnrd3 thioredoxin reductase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 352924, updated on 9-Dec-2024

    Summary

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    Official Symbol
    txnrd3provided by ZNC
    Official Full Name
    thioredoxin reductase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030327-3
    See related
    Ensembl:ENSDARG00000100374 AllianceGenome:ZFIN:ZDB-GENE-030327-3
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    TrxR1; TrxR2; cb682; cb683; txnrd1; fb83a08; wu:fb83a08
    Summary
    The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a TrxR isozyme similar to the third mammalian TrxR, which contains an additional N-terminal glutaredoxin (Grx) domain. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Feb 2018]
    Orthologs
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    Genomic context

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    See txnrd3 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (1161224..1187749, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (661722..688088, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495905 Neighboring gene zinc finger E-box binding homeobox 2b Neighboring gene NACHT, LRR and PYD domains-containing protein 3-like Neighboring gene plexin A1b Neighboring gene uncharacterized LOC100538256

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish (Danio rerio) vary by strain and sex in their behavioral and transcriptional responses to selenium supplementation. Benner MJ, et al. Comp Biochem Physiol A Mol Integr Physiol, 2010 Dec. PMID 20659579, Free PMC Article
    2. The expression of essential selenoproteins during development requires SECIS-binding protein 2-like. Kiledjian NT, et al. Life Sci Alliance, 2022 May. PMID 35210313, Free PMC Article
    3. Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Facchinello N, et al. Cell Death Dis, 2021 Jan 19. PMID 33469036, Free PMC Article
    4. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Sun QA, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11259642, Free PMC Article
    5. Roles of selenoprotein antioxidant protection in zebrafish, Danio rerio, subjected to dietary oxidative stress. Betancor MB, et al. Fish Physiol Biochem, 2015 Jun. PMID 25750091

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin reductase 3
    NP_898895.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183072.2 → NP_898895.2  thioredoxin reductase 3

      Status: REVIEWED

      Source sequence(s)
      BC054599, CABZ01063040, EB861362
      UniProtKB/TrEMBL
      A0A8M1PCD1
      Related
      ENSDARP00000135844.2, ENSDART00000172544.3
      Conserved Domains (5) summary
      cd03419
      Location:25 → 106
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
      TIGR01438
      Location:114 → 602
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:295 → 371
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:474 → 584
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
      cl21454
      Location:114 → 160
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      1161224..1187749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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