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    prickle1a prickle homolog 1a [ Danio rerio (zebrafish) ]

    Gene ID: 368249, updated on 15-Dec-2024

    Summary

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    Official Symbol
    prickle1aprovided by ZNC
    Official Full Name
    prickle homolog 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030724-5
    See related
    Ensembl:ENSDARG00000040649 AllianceGenome:ZFIN:ZDB-GENE-030724-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pk1; fk71b09; prickle1; wu:fk71b09
    Summary
    Predicted to enable zinc ion binding activity. Involved in convergent extension involved in gastrulation and neuron migration. Acts upstream of or within several processes, including Kupffer's vesicle development; determination of left/right symmetry; and nervous system development. Predicted to be located in membrane. Is expressed in several structures, including central nervous system; ectoderm; eye; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prickle1a in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (314608..348784, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (294122..325899, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438376 Neighboring gene periphilin-1 Neighboring gene sizzled Neighboring gene DNA-binding protein RFX7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Veeman MT, et al. Curr Biol, 2003 Apr 15. PMID 12699626
    2. Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis. Mei X, et al. Dis Model Mech, 2013 May. PMID 23324328, Free PMC Article
    3. Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration. Mapp OM, et al. Dev Dyn, 2010 Jun. PMID 20503357, Free PMC Article
    4. Identification and characterization of novel rare mutations in the planar cell polarity gene PRICKLE1 in human neural tube defects. Bosoi CM, et al. Hum Mutat, 2011 Dec. PMID 21901791, Free PMC Article
    5. Tes regulates neural crest migration and axial elongation in Xenopus. Dingwell KS, et al. Dev Biol, 2006 May 1. PMID 16554046

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. uncovered roles for pk1a and pk1b in the epithelial-to-mesenchymal transition (EMT) of pre-migratory NCCs that precedes their collective migration to the periphery.
      Title: Prickle1 is required for EMT and migration of zebrafish cranial neural crest.
    2. Similar to vangl2, loss of zebrafish prickle1a decreases fibronectin protein levels in gastrula embryos.
      Title: Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation.
    3. the wild-type Pk1a partially suppresses the gene knockdown retinal defects but not the mutant forms.
      Title: Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis.
    4. Mechanistically, mir206 targets prickle1a (pk1a) mRNA and as a result regulates c-Jun N-terminal protein kinase 2 (JNK2) phosphorylation.
      Title: MicroRNA-206 regulates cell movements during zebrafish gastrulation by targeting prickle1a and regulating c-Jun N-terminal kinase 2 phosphorylation.
    5. homeodomain gene previously shown to be involved in biliary development and in kidney cyst formation
      Title: Disruption of planar cell polarity activity leads to developmental biliary defects.
    6. Wnt11 and Prickle1a are expressed in the dorsal forerunner cells and regulate Kupffer's vesicle morphogenesis.
      Title: Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Kupffer's vesicle development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within Kupffer's vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell migration in hindbrain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell migration involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in convergent extension involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of digestive tract left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of liver left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of mitotic spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intrahepatic bile duct development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within intrahepatic bile duct development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural retina development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prickle-like protein 1a
    Names
    pk1a
    prickle-like 1 a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183342.2 → NP_899185.2  prickle-like protein 1a

      See identical proteins and their annotated locations for NP_899185.2

      Status: PROVISIONAL

      Source sequence(s)
      AY286492
      UniProtKB/TrEMBL
      Q6WGK5
      Related
      ENSDARP00000059513.5, ENSDART00000059514.7
      Conserved Domains (4) summary
      cd09415
      Location:132 → 191
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:196 → 251
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:256 → 314
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:28 → 124
      PET_Prickle; The PET domain of Prickle

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      314608..348784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005174210.5 → XP_005174267.1  prickle-like protein 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BLU1, F1Q6J9
      Conserved Domains (4) summary
      cd09415
      Location:132 → 191
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:196 → 251
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:256 → 314
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:28 → 124
      PET_Prickle; The PET domain of Prickle
    Nucleotide Protein Strain
    Heading Accession and Version

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