gli1 GLI family zinc finger 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gli1provided by ZNC
Official Full Name: GLI family zinc finger 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030321-1
See related: Ensembl:ENSDARG00000101244 AllianceGenome:ZFIN:ZDB-GENE-030321-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including muscle cell fate specification; nervous system development; and positive regulation of smoothened signaling pathway. Part of Hedgehog signaling complex. Is active in chromatin. Is expressed in several structures, including central nervous system; head; neural plate; neural tube; and paraxial mesoderm. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human GLI1 (GLI family zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (59426148..59505589, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (59433562..59510377, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting of SET/I2PP2A oncoprotein inhibits Gli1 transcription revealing a new modulator of Hedgehog signaling.
Title: Targeting of SET/I2PP2A oncoprotein inhibits Gli1 transcription revealing a new modulator of Hedgehog signaling.
Mutation of hmgcs1 had no effect on Shh signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1, a known Shh target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 mutants.
Title: Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development.
a new mechanism of Gli transcription factor activation and implicate ARHGAP36 dysregulation in the onset and/or progression of GLI-dependent cancers.
Title: Arhgap36-dependent activation of Gli transcription factors.
We show that Kif7 interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 in Drosophila.
Title: Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo.
Gli1 has a Hh-independent role in many motoneurons and V3 domain cells in embryos that lack Hh signalling, but removal of Gli1 activity does not affect more dorsal neurons.
Title: Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons.
Gli1 regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity.
Title: Gsk3beta/PKA and Gli1 regulate the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within abducens nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within abducens nucleus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adenohypophysis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adenohypophysis morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within cranial nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within facial nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within facial nucleus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within floor plate formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within floor plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within generation of neurons	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glossopharyngeal nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube patterning	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube patterning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pituitary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within regulation of neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within smoothened signaling pathway	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trigeminal motor nucleus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trigeminal nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vagus nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventral spinal cord interneuron specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Hedgehog signaling complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein GLI1

Names: GLI-Kruppel family member 1; detour; dtr

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178296.3 → NP_840081.2 zinc finger protein GLI1

Status: VALIDATED

Source sequence(s)

CU693485, CU855923

UniProtKB/TrEMBL

A0A8M1PC25, F1QAC4, Q800Z9

Related

ENSDARP00000129932.1, ENSDART00000170685.3

Conserved Domains (3) summary

COG5189
Location:364 → 454

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:370 → 392

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam09606
Location:853 → 1233

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal