lrrc8aa leucine rich repeat containing 8 VRAC subunit Aa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lrrc8aaprovided by ZNC
Official Full Name: leucine rich repeat containing 8 VRAC subunit Aaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5853
See related: Ensembl:ENSDARG00000032188 AllianceGenome:ZFIN:ZDB-GENE-030131-5853
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lrrc8a; wu:fb18g12; wu:fi21b10
Summary: Enables volume-sensitive anion channel activity. Predicted to be involved in several processes, including aspartate transmembrane transport; cyclic-GMP-AMP transmembrane import across plasma membrane; and monoatomic anion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in head; heart tube; otic vesicle; pectoral fin bud; and ventricular system. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (4256350..4304945)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (4091785..4140380)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leucine-rich repeat containing 8A contributes to the expansion of brain ventricles in zebrafish embryos.
Title: Leucine-rich repeat containing 8A contributes to the expansion of brain ventricles in zebrafish embryos.

Submit: New GeneRIF Correction

General gene information

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Markers

fb18g12.x1 (e-PCR)
- UniSTS:203025

fj59a07.x1 (e-PCR)
- UniSTS:188717

fi21b10.x1 (e-PCR)
- UniSTS:197016

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables volume-sensitive anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables volume-sensitive anion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in aspartate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic anion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leucine rich repeat containing 8 VRAC subunit Aa

Names: leucine rich repeat containing 8 family, member A; leucine rich repeat containing 8 family, member Aa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029949.1 → NP_001025120.1 leucine rich repeat containing 8 VRAC subunit Aa

See identical proteins and their annotated locations for NP_001025120.1

Status: PROVISIONAL

Source sequence(s)

BC097172

UniProtKB/TrEMBL

Q4V8W3

Related

ENSDARP00000120833.2, ENSDART00000148138.3

Conserved Domains (4) summary

cd00116
Location:457 → 772

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:578 → 600

LRR_RI; leucine-rich repeat [structural motif]

pfam12534
Location:1 → 325

Pannexin_like; Pannexin-like TM region of LRRC8

pfam13855
Location:694 → 751

LRR_8; Leucine rich repeat