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    tfb2m transcription factor B2, mitochondrial [ Danio rerio (zebrafish) ]

    Gene ID: 569468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tfb2mprovided by ZNC
    Official Full Name
    transcription factor B2, mitochondrialprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070521-3
    See related
    Ensembl:ENSDARG00000074756 AllianceGenome:ZFIN:ZDB-GENE-070521-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb857
    Summary
    Predicted to enable mitochondrial transcription factor activity and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation and transcription initiation at mitochondrial promoter. Predicted to act upstream of or within methylation and rRNA modification. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including alar plate midbrain region; immature eye; mesoderm; midbrain; and optic primordium. Orthologous to human TFB2M (transcription factor B2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tfb2m in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (12058468..12073356)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (11904402..11919290)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 26Ba Neighboring gene transfer RNA leucine (anticodon UAA) Neighboring gene SET and MYND domain containing 3 Neighboring gene consortin, connexin sorting protein a Neighboring gene saccharopine dehydrogenase a, tandem duplicate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function. Zhang Q, et al. Nucleic Acids Res, 2018 Nov 16. PMID 30137487, Free PMC Article
    2. Srag Regulates Autophagy via Integrating into a Preexisting Autophagy Pathway in Testis. Cheng Y, et al. Mol Biol Evol, 2021 Jan 4. PMID 32722765, Free PMC Article
    3. Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response. Lin YF, et al. iScience, 2021 Oct 22. PMID 34622167, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitochondrial transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within rRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at mitochondrial promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dimethyladenosine transferase 2, mitochondrial
    NP_001107089.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113617.2 → NP_001107089.2  dimethyladenosine transferase 2, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      BX470113, EH461916, EH486004, EH580492
      UniProtKB/TrEMBL
      A0A8M1NFT6, B7ZVD7
      Related
      ENSDARP00000123820.1, ENSDART00000150209.3
      Conserved Domains (2) summary
      cl17173
      Location:112 → 415
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cl21455
      Location:41 → 113
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      12058468..12073356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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