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    fhl3a four and a half LIM domains 3a [ Danio rerio (zebrafish) ]

    Gene ID: 567097, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fhl3aprovided by ZNC
    Official Full Name
    four and a half LIM domains 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4741
    See related
    Ensembl:ENSDARG00000034643 AllianceGenome:ZFIN:ZDB-GENE-030131-4741
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fhl3; fd57e01; wu:fd57e01
    Summary
    Predicted to enable actin binding activity and transcription coregulator activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be active in Z disc; nucleus; and stress fiber. Orthologous to human FHL3 (four and a half LIM domains 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fhl3a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (33656060..33736832)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (33701800..33782805)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene POU class 3 homeobox 1 Neighboring gene UTP11 small subunit processome component Neighboring gene si:ch211-232m19.4 Neighboring gene R-spondin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptomics approach to investigate zebrafish heart regeneration. Sleep E, et al. J Cardiovasc Med (Hagerstown), 2010 May. PMID 20179605
    2. fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles. Dennhag N, et al. Nat Commun, 2024 Mar 2. PMID 38431640, Free PMC Article
    3. Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. Cosse-Etchepare C, et al. Int J Dev Biol, 2018. PMID 29877572
    4. Gene expression profiling of zebrafish embryonic retinal pigment epithelium in vivo. Leung YF, et al. Invest Ophthalmol Vis Sci, 2007 Feb. PMID 17251491, Free PMC Article
    5. Many genes in fish have species-specific asymmetric rates of molecular evolution. Steinke D, et al. BMC Genomics, 2006 Feb 8. PMID 16466575, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    four and a half LIM domains protein 3
    Names
    four and a half LIM domains 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      33656060..33736832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214169.1 → XP_068070270.1  four and a half LIM domains protein 3

      UniProtKB/TrEMBL
      A0A8M9PFP5, E7EZP9

    2. XM_690386.10 → XP_695478.2  four and a half LIM domains protein 3

      UniProtKB/TrEMBL
      A0A8M9PFP5, E7EZP9
      Related
      ENSDARP00000121030.1, ENSDART00000143757.2
      Conserved Domains (5) summary
      cd09346
      Location:162 → 213
      LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
      cd09423
      Location:36 → 94
      LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cd09427
      Location:98 → 155
      LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cd09434
      Location:221 → 276
      LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395326.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      415745..496555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219340.1 → XP_068075441.1  four and a half LIM domains protein 3

      UniProtKB/TrEMBL
      A0A8M9PFP5, E7EZP9

    2. XM_021474356.2 → XP_021330031.1  four and a half LIM domains protein 3

      UniProtKB/TrEMBL
      A0A8M9PFP5, E7EZP9
      Conserved Domains (5) summary
      cd09346
      Location:162 → 213
      LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
      cd09423
      Location:36 → 94
      LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cd09427
      Location:98 → 155
      LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cd09434
      Location:221 → 276
      LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version

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