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    ndufs8a NADH:ubiquinone oxidoreductase core subunit S8a [ Danio rerio (zebrafish) ]

    Gene ID: 406413, updated on 15-Dec-2024

    Summary

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    Official Symbol
    ndufs8aprovided by ZNC
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit S8aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2153
    See related
    Ensembl:ENSDARG00000051986 AllianceGenome:ZFIN:ZDB-GENE-040426-2153
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ndufs8; zgc:65835; zgc:77840; wu:fb30b07
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity; metal ion binding activity; and oxidoreductase activity, acting on NAD(P)H. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Predicted to be located in membrane and mitochondrion. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 2. Orthologous to human NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ndufs8a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (44814364..44823067)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (44113061..44121764)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene si:dkey-9i23.8 Neighboring gene transmembrane protein 187 Neighboring gene syntaxin 3a Neighboring gene lysine (K)-specific demethylase 2Aa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic analysis reveals mitochondrial dysfunction in the pathogenesis of Nager syndrome in sf3b4-depleted zebrafish. Ulhaq ZS, et al. Biochim Biophys Acta Mol Basis Dis, 2024 Apr. PMID 38508476
    2. Analysis of the zebrafish proteome during embryonic development. Lucitt MB, et al. Mol Cell Proteomics, 2008 May. PMID 18212345, Free PMC Article
    3. Aclonifen causes developmental abnormalities in zebrafish embryos through mitochondrial dysfunction and oxidative stress. Lee JY, et al. Sci Total Environ, 2021 Jun 1. PMID 33548715
    4. Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Ozbudak EM, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160088, Free PMC Article
    5. Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Zhang J, et al. Front Endocrinol (Lausanne), 2018. PMID 30631305, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADH:ubiquinone oxidoreductase core subunit S8a
    Names
    NADH dehydrogenase (ubiquinone) Fe-S protein 8, (NADH-coenzyme Q reductase)
    NADH dehydrogenase (ubiquinone) Fe-S protein 8a
    zgNADH dehydrogenase (ubiquinone) Fe-S protein 8, (NADH-coenzyme Q reductase)
    NP_998304.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213139.1 → NP_998304.1  NADH:ubiquinone oxidoreductase core subunit S8a

      See identical proteins and their annotated locations for NP_998304.1

      Status: PROVISIONAL

      Source sequence(s)
      BC058299
      UniProtKB/TrEMBL
      F6P2X1, Q6P0T0, Q6PE39
      Related
      ENSDARP00000059226.4, ENSDART00000059227.5
      Conserved Domains (2) summary
      PRK05888
      Location:54 → 210
      PRK05888; NADH dehydrogenase subunit I; Provisional
      pfam13187
      Location:111 → 161
      Fer4_9; 4Fe-4S dicluster domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      44814364..44823067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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