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    tle3b TLE family member 3, transcriptional corepressor b [ Danio rerio (zebrafish) ]

    Gene ID: 100007463, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tle3bprovided by ZNC
    Official Full Name
    TLE family member 3, transcriptional corepressor bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-85
    See related
    Ensembl:ENSDARG00000069006 AllianceGenome:ZFIN:ZDB-GENE-990415-85
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    grg3; gro1; gro3; GROUCHO1; wu:fi28a02; wu:fj62f10
    Summary
    Predicted to enable transcription corepressor activity. Acts upstream of or within myeloid cell differentiation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including axis; head; mesoderm; pleuroperitoneal region; and unfertilized egg. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tle3b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (33645659..33684691, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (33374862..33413580, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member Vb Neighboring gene uncharacterized LOC137496098 Neighboring gene uveal autoantigen with coiled-coil domains and ankyrin repeats b Neighboring gene relaxin family peptide receptor 3.3a1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation. Kobayashi M, et al. Dev Biol, 2001 Apr 15. PMID 11401394
    2. Two zebrafish homologues of the Drosophila neurogenic gene groucho and their pattern of transcription during early embryogenesis. Wülbeck C, et al. Dev Genes Evol, 1997 Aug. PMID 27747413
    3. Evolution of the Groucho/Tle gene family: gene organization and duplication events. Bajoghli B. Dev Genes Evol, 2007 Aug. PMID 17624551
    4. Balancing cell numbers during organogenesis: Six1a differentially affects neurons and sensory hair cells in the inner ear. Bricaud O, et al. Dev Biol, 2011 Sep 1. PMID 21745464, Free PMC Article
    5. Isolation of nlz2 and characterization of essential domains in Nlz family proteins. Runko AP, et al. J Biol Chem, 2004 Mar 19. PMID 14709556

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transducin-like enhancer protein 3-B
    Names
    groucho 1
    protein groucho-1
    transducin-like enhancer of split 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131780.1 → NP_571855.1  transducin-like enhancer protein 3-B

      See identical proteins and their annotated locations for NP_571855.1

      Status: PROVISIONAL

      Source sequence(s)
      AB040707
      UniProtKB/Swiss-Prot
      O13166, O13168, Q98TH2
      Related
      ENSDARP00000143498.1, ENSDART00000175980.2
      Conserved Domains (4) summary
      cd00200
      Location:483 → 768
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam07271
      Location:147 → 431
      Cytadhesin_P30; Cytadhesin P30/P32
      sd00039
      Location:488 → 527
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      33645659..33684691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222129.1 → XP_068078230.1  transducin-like enhancer protein 3-B isoform X13

      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M3BB05

    2. XM_005168834.5 → XP_005168891.1  transducin-like enhancer protein 3-B isoform X10

      See identical proteins and their annotated locations for XP_005168891.1

      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M2BG40
      Conserved Domains (5) summary
      COG2319
      Location:476 → 768
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:482 → 767
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 142
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      pfam07271
      Location:146 → 430
      Cytadhesin_P30; Cytadhesin P30/P32
      sd00039
      Location:487 → 526
      7WD40; WD40 repeat [structural motif]

    3. XM_068222128.1 → XP_068078229.1  transducin-like enhancer protein 3-B isoform X12

      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M3AU86

    4. XM_068222123.1 → XP_068078224.1  transducin-like enhancer protein 3-B isoform X7

      UniProtKB/Swiss-Prot
      O13166, O13168, Q98TH2
      Related
      ENSDARP00000109120.2, ENSDART00000130553.4

    5. XM_009303191.4 → XP_009301466.1  transducin-like enhancer protein 3-B isoform X1

      See identical proteins and their annotated locations for XP_009301466.1

      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M3AU69
      Conserved Domains (5) summary
      COG2319
      Location:488 → 780
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:494 → 779
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 124
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      pfam07271
      Location:158 → 442
      Cytadhesin_P30; Cytadhesin P30/P32
      sd00039
      Location:499 → 538
      7WD40; WD40 repeat [structural motif]

    6. XM_068222124.1 → XP_068078225.1  transducin-like enhancer protein 3-B isoform X7

      UniProtKB/Swiss-Prot
      O13166, O13168, Q98TH2

    7. XM_009303204.4 → XP_009301479.1  transducin-like enhancer protein 3-B isoform X16

      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M3B175
      Conserved Domains (6) summary
      PHA03249
      Location:252 → 388
      PHA03249; DNA packaging tegument protein UL25; Provisional
      COG2319
      Location:465 → 757
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:471 → 756
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      pfam07271
      Location:136 → 419
      Cytadhesin_P30; Cytadhesin P30/P32
      sd00039
      Location:476 → 515
      7WD40; WD40 repeat [structural motif]

    8. XM_009303202.4 → XP_009301477.1  transducin-like enhancer protein 3-B isoform X14

      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M3AU78
      Conserved Domains (5) summary
      COG2319
      Location:466 → 758
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:472 → 757
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      pfam07271
      Location:136 → 420
      Cytadhesin_P30; Cytadhesin P30/P32
      sd00039
      Location:477 → 516
      7WD40; WD40 repeat [structural motif]

    9. XM_009303203.4 → XP_009301478.1  transducin-like enhancer protein 3-B isoform X15

      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M3B444
      Conserved Domains (6) summary
      PHA03249
      Location:253 → 389
      PHA03249; DNA packaging tegument protein UL25; Provisional
      COG2319
      Location:466 → 758
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:472 → 757
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      pfam07271
      Location:137 → 420
      Cytadhesin_P30; Cytadhesin P30/P32
      sd00039
      Location:477 → 516
      7WD40; WD40 repeat [structural motif]

    10. XM_068222126.1 → XP_068078227.1  transducin-like enhancer protein 3-B isoform X11

      UniProtKB/Swiss-Prot
      O13166

    11. XM_009303198.4 → XP_009301473.1  transducin-like enhancer protein 3-B isoform X8

      UniProtKB/TrEMBL
      A0A8M3B441
      Conserved Domains (5) summary
      COG2319
      Location:477 → 769
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:483 → 768
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 126
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      pfam07271
      Location:147 → 431
      Cytadhesin_P30; Cytadhesin P30/P32
      sd00039
      Location:488 → 527
      7WD40; WD40 repeat [structural motif]

    12. XM_068222125.1 → XP_068078226.1  transducin-like enhancer protein 3-B isoform X9

      UniProtKB/Swiss-Prot
      O13166

    13. XM_068222122.1 → XP_068078223.1  transducin-like enhancer protein 3-B isoform X6

    14. XM_009303196.4 → XP_009301471.1  transducin-like enhancer protein 3-B isoform X5

      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M3AU75
      Conserved Domains (5) summary
      COG2319
      Location:486 → 778
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:492 → 777
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      pfam07271
      Location:156 → 440
      Cytadhesin_P30; Cytadhesin P30/P32
      sd00039
      Location:497 → 536
      7WD40; WD40 repeat [structural motif]

    15. XM_009303193.4 → XP_009301468.1  transducin-like enhancer protein 3-B isoform X2

      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M3B166
      Conserved Domains (5) summary
      COG2319
      Location:487 → 779
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:493 → 778
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 124
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      pfam07271
      Location:157 → 441
      Cytadhesin_P30; Cytadhesin P30/P32
      sd00039
      Location:498 → 537
      7WD40; WD40 repeat [structural motif]

    16. XM_009303194.4 → XP_009301469.1  transducin-like enhancer protein 3-B isoform X3

      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M3AU81
      Conserved Domains (5) summary
      COG2319
      Location:487 → 779
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:493 → 778
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 153
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      pfam07271
      Location:157 → 441
      Cytadhesin_P30; Cytadhesin P30/P32
      sd00039
      Location:498 → 537
      7WD40; WD40 repeat [structural motif]

    17. XM_009303195.4 → XP_009301470.1  transducin-like enhancer protein 3-B isoform X4

      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M3BB02
      Conserved Domains (5) summary
      PHA03249
      Location:274 → 410
      PHA03249; DNA packaging tegument protein UL25; Provisional
      COG2319
      Location:487 → 779
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:493 → 778
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 124
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:498 → 537
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O13168.2 GenPept UniProtKB/Swiss-Prot:O13168

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