acadl acyl-CoA dehydrogenase long chain [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: acadlprovided by ZNC
Official Full Name: acyl-CoA dehydrogenase long chainprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-771
See related: Ensembl:ENSDARG00000088357 AllianceGenome:ZFIN:ZDB-GENE-040426-771
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55656
Summary: Predicted to enable flavin adenine dinucleotide binding activity; long-chain fatty acyl-CoA dehydrogenase activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in carnitine metabolic process, CoA-linked; fatty acid beta-oxidation using acyl-CoA dehydrogenase; and long-chain fatty acid catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in female organism; subcutaneous fat; and visceral fat. Orthologous to human ACADL (acyl-CoA dehydrogenase long chain). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (39487513..39505851)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (39506505..39524843)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables palmitoyl-CoA oxidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in carnitine metabolic process, CoA-linked	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-chain fatty acid catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: long-chain specific acyl-CoA dehydrogenase, mitochondrial

Names: LCAD; acyl-Coenzyme A dehydrogenase, long chain

NP_957475.1

EC 1.3.8.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201181.2 → NP_957475.1 long-chain specific acyl-CoA dehydrogenase, mitochondrial

See identical proteins and their annotated locations for NP_957475.1

Status: PROVISIONAL

Source sequence(s)

BC044447

UniProtKB/TrEMBL

Q7ZYX3

Related

ENSDARP00000108139.2, ENSDART00000126978.3

Conserved Domains (2) summary

cd01160
Location:67 → 439

LCAD; Long chain acyl-CoA dehydrogenase

COG1960
Location:65 → 439

CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]