c1s.2 complement component 1, s subcomponent .2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: c1s.2provided by ZNC
Official Full Name: complement component 1, s subcomponent .2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4645
See related: Ensembl:ENSDARG00000102094 AllianceGenome:ZFIN:ZDB-GENE-030131-4645
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fd46c06; wu:fd46c06
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within complement activation, classical pathway; innate immune response; and proteolysis. Predicted to be active in extracellular space. Orthologous to human C1RL (complement C1r subcomponent like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (31658193..31661556, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (31701206..31704522, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uncharacterized protein LOC793504

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114449.2 → NP_001107921.2 uncharacterized protein LOC793504 precursor

Status: VALIDATED

Source sequence(s)

LO017669

UniProtKB/TrEMBL

A9JSU2

Related

ENSDARP00000135637.2, ENSDART00000169973.2

Conserved Domains (2) summary

smart00020
Location:217 → 450

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:25 → 133

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.