pou3f2b POU class 3 homeobox 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pou3f2bprovided by ZNC
Official Full Name: POU class 3 homeobox 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-370
See related: Ensembl:ENSDARG00000076262 AllianceGenome:ZFIN:ZDB-GENE-980526-370
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zp47; pou47; pou3f2; zp47pou
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within endothelial cell development. Predicted to be located in nucleus. Is expressed in central nervous system; midbrain neural keel; neural rod; and presumptive diencephalon. Orthologous to human POU3F2 (POU class 3 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (32559821..32563092)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (32605791..32609062)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using morpholino and mutant zebrafish models, we show that POU3F2 lies downstream of SIM1 and controls oxytocin expression in the hypothalamic neuroendocrine preoptic area.
Title: Small 6q16.1 Deletions Encompassing POU3F2 Cause Susceptibility to Obesity and Variable Developmental Delay with Intellectual Disability.

Submit: New GeneRIF Correction

General gene information

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Markers

ZP47POU (e-PCR)
- UniSTS:205399

pou47 (e-PCR), detects polymorphism
- UniSTS:205529

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: POU domain, class 3, transcription factor 2

Names: POU class 3 homeobox 2; POU domain gene 47; POU domain protein 47; POU domain protein ZP-47; ZP-47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131160.1 → NP_571235.1 POU domain, class 3, transcription factor 2

See identical proteins and their annotated locations for NP_571235.1

Status: PROVISIONAL

Source sequence(s)

Y07905

UniProtKB/Swiss-Prot

B0S5F1, P79746

Related

ENSDARP00000087682.4, ENSDART00000093250.6

Conserved Domains (2) summary

smart00352
Location:200 → 274

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:295 → 348

Homeobox; Homeobox domain