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    map3k4 mitogen-activated protein kinase kinase kinase 4 [ Danio rerio (zebrafish) ]

    Gene ID: 325488, updated on 9-Dec-2024

    Summary

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    Official Symbol
    map3k4provided by ZNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990603-4
    See related
    Ensembl:ENSDARG00000104835 AllianceGenome:ZFIN:ZDB-GENE-990603-4
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb135; mekk4; wu:fc83c01
    Summary
    Predicted to enable ATP binding activity and MAP kinase kinase kinase activity. Predicted to be involved in p38MAPK cascade. Predicted to act upstream of or within MAPK cascade and protein phosphorylation. Is expressed in several structures, including mesoderm; nervous system; neural plate; primordial germ cell; and tail bud. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See map3k4 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (35787873..35844969, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (35662312..35719599, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 75 Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Neighboring gene potassium channel, subfamily K, member 1b Neighboring gene transforming, acidic coiled-coil containing protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes. Johnston IA, et al. J Exp Biol, 2009 Jun. PMID 19482995
    2. A genetic linkage map for zebrafish: comparative analysis and localization of genes and expressed sequences. Gates MA, et al. Genome Res, 1999 Apr. PMID 10207156
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 4
    Names
    MAP/ERK kinase kinase 4
    XP_009305769.1
    XP_009305770.1
    XP_009305771.1
    XP_021336557.1
    XP_068069183.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      35787873..35844969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480882.2 → XP_021336557.1  mitogen-activated protein kinase kinase kinase 4 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PYS2
      Conserved Domains (1) summary
      cd06626
      Location:1239 → 1498
      STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

    2. XM_009307495.4 → XP_009305770.1  mitogen-activated protein kinase kinase kinase 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B5F7
      Conserved Domains (2) summary
      smart00220
      Location:1274 → 1532
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06626
      Location:1273 → 1532
      STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

    3. XM_009307496.4 → XP_009305771.1  mitogen-activated protein kinase kinase kinase 4 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AZE2
      Conserved Domains (2) summary
      smart00220
      Location:1241 → 1499
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06626
      Location:1240 → 1499
      STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

    4. XM_009307494.4 → XP_009305769.1  mitogen-activated protein kinase kinase kinase 4 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IK63, A0A8M3B876
      Related
      ENSDARP00000133970.1, ENSDART00000171371.2
      Conserved Domains (2) summary
      smart00220
      Location:1275 → 1533
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06626
      Location:1274 → 1533
      STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

    5. XM_068213082.1 → XP_068069183.1  mitogen-activated protein kinase kinase kinase 4 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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