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    cpne3 copine III [ Danio rerio (zebrafish) ]

    Gene ID: 393136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpne3provided by ZNC
    Official Full Name
    copine IIIprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-763
    See related
    Ensembl:ENSDARG00000104177 AllianceGenome:ZFIN:ZDB-GENE-040426-763
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55622
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity and receptor tyrosine kinase binding activity. Predicted to be involved in ERBB2 signaling pathway and cellular response to calcium ion. Predicted to be active in plasma membrane. Orthologous to human CPNE3 (copine 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cpne3 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (31374383..31405794)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (31437168..31468587)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 168 member B Neighboring gene cAMP responsive element modulator b Neighboring gene cyclic nucleotide gated channel subunit beta 3, tandem duplicate 1 Neighboring gene cyclic nucleotide-gated channel beta-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC55622

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERBB2 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    copine-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200167.1 → NP_956461.1  copine-3

      See identical proteins and their annotated locations for NP_956461.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045408
      UniProtKB/TrEMBL
      Q7ZVU4
      Related
      ENSDARP00000140742.1, ENSDART00000163162.2
      Conserved Domains (3) summary
      cd04047
      Location:139 → 250
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:7 → 125
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:264 → 513
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      31374383..31405794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162840.5 → XP_005162897.1  copine-3 isoform X2

      UniProtKB/TrEMBL
      A0A0R4IUW1, A0A8M2B9S3
      Conserved Domains (3) summary
      cd04047
      Location:139 → 250
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:7 → 125
      C2A_Copine; C2 domain first repeat in Copine
      pfam07002
      Location:309 → 526
      Copine; Copine

    2. XM_005162839.5 → XP_005162896.1  copine-3 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BA35, F1Q9D2
      Related
      ENSDARP00000139825.2, ENSDART00000172335.2
      Conserved Domains (3) summary
      cd04047
      Location:139 → 250
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:7 → 125
      C2A_Copine; C2 domain first repeat in Copine
      pfam07002
      Location:309 → 526
      Copine; Copine

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395182.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      197369..225632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395367.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      203546..232270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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