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    acsl1a acyl-CoA synthetase long chain family member 1a [ Danio rerio (zebrafish) ]

    Gene ID: 555308, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acsl1aprovided by ZNC
    Official Full Name
    acyl-CoA synthetase long chain family member 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050809-115
    See related
    Ensembl:ENSDARG00000030514 AllianceGenome:ZFIN:ZDB-GENE-050809-115
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    acsl1; zgc:110081
    Summary
    Predicted to enable arachidonate-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA biosynthetic process; and very long-chain fatty acid metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Orthologous to human ACSL1 (acyl-CoA synthetase long chain family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See acsl1a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (17537322..17587554, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (16844385..16894630, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene FAT atypical cadherin 1a Neighboring gene caspase 3, apoptosis-related cysteine peptidase a Neighboring gene si:ch211-197n1.2 Neighboring gene helt bHLH transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Diversity and history of the long-chain acyl-CoA synthetase (Acsl) gene family in vertebrates. Lopes-Marques M, et al. BMC Evol Biol, 2013 Dec 12. PMID 24330521, Free PMC Article
    2. Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway. Gao P, et al. Invest Ophthalmol Vis Sci, 2022 May 2. PMID 35616930, Free PMC Article
    3. Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish. Nath AK, et al. FASEB J, 2020 Jan. PMID 31914600, Free PMC Article
    4. Dysregulatory effects of retinoic acid isomers in late zebrafish embryos. Navarro-Martín L, et al. Environ Sci Pollut Res Int, 2018 Feb. PMID 29178002
    5. Cannabinoid receptor 1 promotes hepatic lipid accumulation and lipotoxicity through the induction of SREBP-1c expression in zebrafish. Pai WY, et al. Transgenic Res, 2013 Aug. PMID 23315130

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110081

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    long-chain-fatty-acid--CoA ligase 1a
    Names
    acyl-CoA synthetase long-chain family member 1
    NP_001027007.1
    XP_005168406.1
    XP_005168407.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031837.1 → NP_001027007.1  long-chain-fatty-acid--CoA ligase 1a

      See identical proteins and their annotated locations for NP_001027007.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100000
      UniProtKB/TrEMBL
      Q499A9
      Related
      ENSDARP00000039916.5, ENSDART00000039917.7
      Conserved Domains (2) summary
      PLN02736
      Location:88 → 695
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:116 → 692
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      17537322..17587554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168350.5 → XP_005168407.1  long-chain-fatty-acid--CoA ligase 1a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BFN1
      Conserved Domains (2) summary
      PLN02736
      Location:88 → 695
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:116 → 692
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    2. XM_005168349.5 → XP_005168406.1  long-chain-fatty-acid--CoA ligase 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BFN5, B8JK22
      Related
      ENSDARP00000105676.1, ENSDART00000125125.3
      Conserved Domains (2) summary
      PLN02736
      Location:88 → 695
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:116 → 692
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394470.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      361970..410943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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