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    f9a coagulation factor IXa [ Danio rerio (zebrafish) ]

    Gene ID: 359826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    f9aprovided by ZNC
    Official Full Name
    coagulation factor IXaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030714-2
    See related
    Ensembl:ENSDARG00000010097 AllianceGenome:ZFIN:ZDB-GENE-030714-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    f9; zgc:109775
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in X-linked thrombophilia due to factor IX defect; X-linked warfarin sensitivity; and hemophilia B. Orthologous to human F9 (coagulation factor IX). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See f9a in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (32430982..32438197)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (32090668..32097883)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:ch211-69b22.5 Neighboring gene fibroblast growth factor 13a Neighboring gene MCF.2 cell line derived transforming sequence a Neighboring gene ATPase phospholipid transporting 11C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of zebrafish ortholog for human coagulation factor IX and its age-dependent expression. Iyer N, et al. J Thromb Haemost, 2021 Sep. PMID 33974340
    2. Comprehensive analysis of blood coagulation pathways in teleostei: evolution of coagulation factor genes and identification of zebrafish factor VIIi. Hanumanthaiah R, et al. Blood Cells Mol Dis, 2002 Jul-Aug. PMID 12482404
    3. A novel conserved enhancer at zebrafish zic3 and zic6 loci drives neural expression. Minhas R, et al. Dev Dyn, 2019 Sep. PMID 31194899, Free PMC Article
    4. Insights into the evolutionary history of the vertebrate zic3 locus from a teleost-specific zic6 gene in the zebrafish, Danio rerio. Keller MJ, et al. Dev Genes Evol, 2007 Jul. PMID 17503076
    5. Expression of three P4-phospholipid flippases-atp11a, atp11b, and atp11c in zebrafish (Danio rerio). Hawkey-Noble A, et al. Gene Expr Patterns, 2020 Jun. PMID 32344036

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of zebrafish ortholog for human coagulation factor IX and its age-dependent expression.
      Title: Identification of zebrafish ortholog for human coagulation factor IX and its age-dependent expression.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coagulation factor IXa
    Names
    coagulation factor IX
    NP_878288.2
    XP_005173258.1
    XP_068069273.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182868.2 → NP_878288.2  coagulation factor IXa precursor

      Status: VALIDATED

      Source sequence(s)
      BX004988, EH490346, EH506608, EH516696, EH532764
      UniProtKB/TrEMBL
      A0A8M1PEI6, E7F301
      Related
      ENSDARP00000022674.6, ENSDART00000017179.8
      Conserved Domains (5) summary
      smart00020
      Location:253 → 486
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:19 → 83
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:84 → 120
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:254 → 489
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:127 → 163
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      32430982..32438197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213172.1 → XP_068069273.1  coagulation factor IXa isoform X1

    2. XM_005173201.5 → XP_005173258.1  coagulation factor IXa isoform X2

      UniProtKB/TrEMBL
      A0A8M2BL01
      Related
      ENSDARP00000070075.6, ENSDART00000075593.6
      Conserved Domains (3) summary
      smart00020
      Location:170 → 403
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:19 → 83
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00190
      Location:171 → 406
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394916.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      52520..59735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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