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    ctsla cathepsin La [ Danio rerio (zebrafish) ]

    Gene ID: 321453, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ctslaprovided by ZNC
    Official Full Name
    cathepsin Laprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-106
    See related
    Ensembl:ENSDARG00000007836 AllianceGenome:ZFIN:ZDB-GENE-030131-106
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ctsl1a; sb:cb143; hm:zeh1631; wu:fb70e06; wu:fi15c08; tdsubc_2f10; ik:tdsubc_2d2; xx:tdsubc_2d2; ik:tdsubc_2f10; xx:tdsubc_2f10
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Is expressed in blood; digestive system; gill; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSL (cathepsin L). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ctsla in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (44804824..44810915)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (44204647..44210762)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495625 Neighboring gene death-associated protein kinase 1 Neighboring gene fructose-1,6-bisphosphatase 2 Neighboring gene fructose-1,6-bisphosphatase 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of Lactobacillus rhamnosus on zebrafish oocyte maturation: an FTIR imaging and biochemical analysis. Giorgini E, et al. Anal Bioanal Chem, 2010 Dec. PMID 20936269
    2. Molecular cloning and mRNA expression of the liver-specific cathepsin L1 gene of the olive flounder, Paralichthys olivaceus. Kim YO, et al. Biosci Biotechnol Biochem, 2011. PMID 21670505
    3. The evolutionary legacy of size-selective harvesting extends from genes to populations. Uusi-Heikkilä S, et al. Evol Appl, 2015 Jul. PMID 26136825, Free PMC Article
    4. Inhibition of Embryonic HSP 90 Function Promotes Variation of Cold Tolerance in Zebrafish. Han B, et al. Front Genet, 2020. PMID 33343615, Free PMC Article
    5. Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation. Lu PN, et al. JCI Insight, 2020 Oct 15. PMID 33055423, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ctsla is most likely the putative protease involved in yolk processing in zebrafish embryos.
      Title: Phylogenetic relationships and gene expression pattern of three different cathepsin L (Ctsl) isoforms in zebrafish: Ctsla is the putative yolk processing enzyme.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cathepsin La
    Names
    cathepsin L, 1 a
    cathepsin L, a
    NP_997749.1
    XP_005165325.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212584.1 → NP_997749.1  cathepsin La precursor

      See identical proteins and their annotated locations for NP_997749.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066490
      UniProtKB/TrEMBL
      A0A8M9PJP2, A5WVL6, Q6NYR5
      Related
      ENSDARP00000157273.1, ENSDART00000184237.1
      Conserved Domains (2) summary
      smart00848
      Location:29 → 87
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:116 → 336
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      44804824..44810915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165268.3 → XP_005165325.1  cathepsin La isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCJ2, A0A8M9PJP2, A5WVL6
      Conserved Domains (2) summary
      smart00848
      Location:55 → 113
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:142 → 362
      Peptidase_C1; Papain family cysteine protease
    Nucleotide Protein
    Heading Accession and Version

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