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    baz2a bromodomain adjacent to zinc finger domain, 2A [ Danio rerio (zebrafish) ]

    Gene ID: 450079, updated on 9-Dec-2024

    Summary

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    Official Symbol
    baz2aprovided by ZNC
    Official Full Name
    bromodomain adjacent to zinc finger domain, 2Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-202
    See related
    Ensembl:ENSDARG00000102974 AllianceGenome:ZFIN:ZDB-GENE-041010-202
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:101601
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in rDNA heterochromatin. Orthologous to human BAZ2A (bromodomain adjacent to zinc finger domain 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See baz2a in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (6673299..6727718, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (6739327..6793746, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene aquaporin-4 Neighboring gene major intrinsic protein of lens fiber b Neighboring gene prostaglandin E synthase 3b (cytosolic) Neighboring gene secreted frizzled-related protein 5 Neighboring gene prolyl 4-hydroxylase, transmembrane a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in rDNA heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain adjacent to zinc finger domain protein 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320131.1 → NP_001307060.1  bromodomain adjacent to zinc finger domain protein 2A

      Status: VALIDATED

      Source sequence(s)
      CR450824, FP102118, FP102169
      UniProtKB/TrEMBL
      A0A0R4IVN8, A0A8M1P2D8
      Conserved Domains (6) summary
      cd05503
      Location:2355 → 2451
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      cd01397
      Location:1049 → 1123
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:2235 → 2281
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam15613
      Location:1971 → 2004
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl02674
      Location:1389 → 1451
      DDT; DDT domain
      cl26464
      Location:298 → 629
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      6673299..6727718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469791.2 → XP_021325466.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A0R4IVN8, A0A8M1P2D8
      Related
      ENSDARP00000139219.1, ENSDART00000157828.2
      Conserved Domains (6) summary
      cd05503
      Location:2355 → 2451
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      cd01397
      Location:1049 → 1123
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:2235 → 2281
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam15613
      Location:1971 → 2004
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl02674
      Location:1389 → 1451
      DDT; DDT domain
      cl26464
      Location:298 → 629
      Atrophin-1; Atrophin-1 family

    2. XM_068216743.1 → XP_068072844.1  bromodomain adjacent to zinc finger domain protein 2A isoform X3

    3. XM_021469792.2 → XP_021325467.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A8M9P535
      Conserved Domains (6) summary
      cd05503
      Location:2333 → 2429
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      cd01397
      Location:1049 → 1123
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:2213 → 2259
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam15613
      Location:1971 → 2004
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl02674
      Location:1389 → 1451
      DDT; DDT domain
      cl26464
      Location:298 → 629
      Atrophin-1; Atrophin-1 family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001006099.1: Suppressed sequence

      Description
      NM_001006099.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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