tyr tyrosinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tyrprovided by ZNC
Official Full Name: tyrosinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-991026-3
See related: Ensembl:ENSDARG00000039077 AllianceGenome:ZFIN:ZDB-GENE-991026-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sandy; zgc:109705
Summary: Enables catechol oxidase activity. Acts upstream of or within several processes, including dopamine biosynthetic process from tyrosine; iridophore differentiation; and melanosome organization. Predicted to be located in melanosome membrane. Is expressed in several structures, including eye; male organism; melanoblast; neural crest; and presumptive retinal pigmented epithelium. Used to study color blindness and oculocutaneous albinism. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (tyrosinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (43799258..43818704)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (43776250..43795340)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UP256 Inhibits Hyperpigmentation by Tyrosinase Expression/Dendrite Formation via Rho-Dependent Signaling and by Primary Cilium Formation in Melanocytes.
Title: UP256 Inhibits Hyperpigmentation by Tyrosinase Expression/Dendrite Formation via Rho-Dependent Signaling and by Primary Cilium Formation in Melanocytes.
Nicastrin Deficiency Induces Tyrosinase-Dependent Depigmentation and Skin Inflammation.
Title: Nicastrin Deficiency Induces Tyrosinase-Dependent Depigmentation and Skin Inflammation.
Using our system, conditional TYR knockout in zebrafish was achieved efficiently and simply.
Title: Heat-shock-induced tyrosinase gene ablation with CRISPR in zebrafish.
Retinal pigment epithelium (which normally expresses tyrosinase) secretes a modulatory factor, possibly L-DOPA, which regulates light adaptation in the retinal circuitry.
Title: Retinal network adaptation to bright light requires tyrosinase.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catechol oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables tyrosinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopamine biosynthetic process from tyrosine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within iridophore differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in melanosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosinase

Names: oca1; sdy; tyra

NP_571088.3

EC 1.14.18.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131013.3 → NP_571088.3 tyrosinase precursor

Status: VALIDATED

Source sequence(s)

CABZ01073031, CABZ01073032, FQ377957

UniProtKB/TrEMBL

A0A8M1PAD4

Related

ENSDARP00000111575.2, ENSDART00000122238.3

Conserved Domains (2) summary

pfam00264
Location:172 → 405

Tyrosinase; Common central domain of tyrosinase

cl21504
Location:89 → 110

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...