nudt8 nudix hydrolase 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nudt8provided by ZNC
Official Full Name: nudix hydrolase 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-061013-219
See related: Ensembl:ENSDARG00000007722 AllianceGenome:ZFIN:ZDB-GENE-061013-219
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:153051
Summary: Predicted to enable coenzyme A diphosphatase activity and metal ion binding activity. Orthologous to human NUDT8 (nudix hydrolase 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (499839..506032, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (539034..545231, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables coenzyme A diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: mitochondrial coenzyme A diphosphatase NUDT8

Names: nudix (nucleoside diphosphate linked moiety X)-type motif 8

NP_001070784.2

EC 3.6.1.77

XP_009289624.1

EC 3.6.1.77

XP_021337150.1

EC 3.6.1.77

XP_021337151.1

EC 3.6.1.77

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077316.2 → NP_001070784.2 mitochondrial coenzyme A diphosphatase NUDT8

Status: VALIDATED

Source sequence(s)

CU469536

UniProtKB/TrEMBL

Q08BP5

Related

ENSDARP00000129549.2, ENSDART00000155472.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

499839..506032 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021481476.2 → XP_021337151.1 mitochondrial coenzyme A diphosphatase NUDT8 isoform X2

UniProtKB/TrEMBL

A0A8M9QLI7

Conserved Domains (1) summary

cd03426
Location:178 → 282

CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
XM_009291349.4 → XP_009289624.1 mitochondrial coenzyme A diphosphatase NUDT8 isoform X3

UniProtKB/TrEMBL

A0A8M3B0L6

Conserved Domains (1) summary

cd03426
Location:178 → 264

CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
XM_021481475.2 → XP_021337150.1 mitochondrial coenzyme A diphosphatase NUDT8 isoform X1

UniProtKB/TrEMBL

A0A8M9QPZ0

Conserved Domains (1) summary

cd03426
Location:178 → 264

CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...