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    ggt5a gamma-glutamyltransferase 5a [ Danio rerio (zebrafish) ]

    Gene ID: 569734, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ggt5aprovided by ZNC
    Official Full Name
    gamma-glutamyltransferase 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080226-1
    See related
    Ensembl:ENSDARG00000052045 AllianceGenome:ZFIN:ZDB-GENE-080226-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ggt5
    Summary
    Predicted to enable glutathione hydrolase activity and leukotriene-C(4) hydrolase. Predicted to be involved in glutathione catabolic process; inflammatory response; and leukotriene D4 biosynthetic process. Predicted to be active in plasma membrane. Orthologous to human GGT5 (gamma-glutamyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ggt5a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (39998507..40028441)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (39964722..39995239)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 1a Neighboring gene aspartate beta-hydroxylase domain containing 2 Neighboring gene gamma-glutamyltransferase 1a Neighboring gene leucine rich repeat containing 75Ba Neighboring gene uncharacterized LOC137496378

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative genomics of duplicate γ-glutamyl transferase genes in teleosts: medaka (Oryzias latipes), stickleback (Gasterosteus aculeatus), green spotted pufferfish (Tetraodon nigroviridis), fugu (Takifugu rubripes), and zebrafish (Danio rerio). Law SH, et al. J Exp Zool B Mol Dev Evol, 2012 Jan 15. PMID 21898790, Free PMC Article
    2. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Timme-Laragy AR, et al. Free Radic Biol Med, 2013 Dec. PMID 23770340, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene C4 gamma-glutamyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene-C(4) hydrolase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene D4 biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gamma-glutamyltransferase 5a
    Names
    gamma-glutamyltransferase 5
    ggtla1
    NP_001116770.1
    XP_005167440.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123298.1 → NP_001116770.1  gamma-glutamyltransferase 5a

      Status: PROVISIONAL

      Source sequence(s)
      CR388077
      UniProtKB/TrEMBL
      A0A8M1NIH9, B0UXV4
      Related
      ENSDARP00000116811.1, ENSDART00000134452.2
      Conserved Domains (1) summary
      cl19223
      Location:58 → 508
      G_glu_transpept; Gamma-glutamyltranspeptidase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      39998507..40028441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167383.5 → XP_005167440.1  gamma-glutamyltransferase 5a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BET1, E9QDV5
      Related
      ENSDARP00000068272.5, ENSDART00000073782.8
      Conserved Domains (1) summary
      pfam01019
      Location:58 → 551
      G_glu_transpept; Gamma-glutamyltranspeptidase
    Nucleotide Protein Strain
    Heading Accession and Version

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