tdp1 tyrosyl-DNA phosphodiesterase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tdp1provided by ZNC
Official Full Name: tyrosyl-DNA phosphodiesterase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-090909-1
See related: Ensembl:ENSDARG00000073866 AllianceGenome:ZFIN:ZDB-GENE-090909-1
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands. Involved in adult locomotory behavior. Predicted to be active in nucleus. Is expressed in head. Human ortholog(s) of this gene implicated in spinocerebellar ataxia with axonal neuropathy 1. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (16348830..16422624, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (16340896..16414678, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA-protein crosslinks in vivo.
Title: Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA-protein crosslinks in vivo.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables 3'-tyrosyl-DNA phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

XP_700174.2

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The following sections contain reference sequences that belong to a specific genome build. Explain