cd248b CD248 molecule, endosialin b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cd248bprovided by ZNC
Official Full Name: CD248 molecule, endosialin bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050309-46
See related: Ensembl:ENSDARG00000077938 AllianceGenome:ZFIN:ZDB-GENE-050309-46
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TM-b; im:7144089; si:ch211-123o7.5
Summary: Predicted to enable extracellular matrix binding activity and extracellular matrix protein binding activity. Acts upstream of or within regulation of innate immune response and response to lipopolysaccharide. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including blastoderm; blood vessel; head; internal yolk syncytial layer; and primordial vasculature. Orthologous to human CD248 (CD248 molecule). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (26492126..26495843, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic Sequence:: NC_007132.7 Chromosome 21 Reference GRCz11 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Cd248a and Cd248b in zebrafish participate in innate immune responses.
Title: Cd248a and Cd248b in zebrafish participate in innate immune responses.
Thrombomodulin-b (TM-b) is crucial to the collective migration of blastomeres during germ layer formation (.
Title: A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish.

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Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain