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    msi2b musashi RNA-binding protein 2b [ Danio rerio (zebrafish) ]

    Gene ID: 394084, updated on 9-Dec-2024

    Summary

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    Official Symbol
    msi2bprovided by ZNC
    Official Full Name
    musashi RNA-binding protein 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1268
    See related
    Ensembl:ENSDARG00000032614 AllianceGenome:ZFIN:ZDB-GENE-040426-1268
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    msi2; zgc:63812; zgc:174035
    Summary
    Predicted to enable mRNA binding activity. Acts upstream of or within olfactory bulb development. Predicted to be active in cytoplasm. Is expressed in nervous system and otic vesicle. Orthologous to human MSI2 (musashi RNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See msi2b in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (30424122..30816514, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (30543904..30935842, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103908846 Neighboring gene mitochondrial ribosomal protein S23 Neighboring gene uncharacterized LOC137487763 Neighboring gene uncharacterized LOC137487764

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish stem/progenitor factor msi2b exhibits two phases of activity mediated by different splice variants. Hochgreb-Hägele T, et al. Stem Cells, 2014 Feb. PMID 24420905, Free PMC Article
    2. Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. McGrail M, et al. PLoS One, 2011 Apr 21. PMID 21533036, Free PMC Article
    3. A spinal organ of proprioception for integrated motor action feedback. Picton LD, et al. Neuron, 2021 Apr 7. PMID 33577748
    4. Comprehensive analysis of target genes in zebrafish embryos reveals gbx2 involvement in neurogenesis. Nakayama Y, et al. Dev Biol, 2017 Oct 1. PMID 28756106
    5. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Trinh le A, et al. Genes Dev, 2011 Nov 1. PMID 22056673, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This line provides a valuable tool both for live imaging of the endogenous Msi2b at subcellular resolution and manipulation of Msi2b-expressing cells.
      Title: Zebrafish stem/progenitor factor msi2b exhibits two phases of activity mediated by different splice variants.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63812, MGC174035

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within olfactory bulb development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein Musashi homolog 2b
    Names
    musashi homolog 2
    musashi homolog 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201109.1 → NP_957403.1  RNA-binding protein Musashi homolog 2b

      See identical proteins and their annotated locations for NP_957403.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055251
      UniProtKB/TrEMBL
      A0A8N7V033, Q7SXT6
      Related
      ENSDARP00000090967.2, ENSDART00000100194.5
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      30424122..30816514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157685.5 → XP_005157742.1  RNA-binding protein Musashi homolog 2b isoform X5

      UniProtKB/TrEMBL
      A0A8M2B3X1
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    2. XM_005157687.5 → XP_005157744.1  RNA-binding protein Musashi homolog 2b isoform X11

      UniProtKB/TrEMBL
      A0A8M2B414
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    3. XM_068213496.1 → XP_068069597.1  RNA-binding protein Musashi homolog 2b isoform X5

      UniProtKB/TrEMBL
      A0A8M2B3X1

    4. XM_005157686.5 → XP_005157743.1  RNA-binding protein Musashi homolog 2b isoform X9

      UniProtKB/TrEMBL
      A0A8M2B3X4
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    5. XM_005157682.5 → XP_005157739.1  RNA-binding protein Musashi homolog 2b isoform X3

      UniProtKB/TrEMBL
      A0A8M2B4J9
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    6. XM_009291633.4 → XP_009289908.1  RNA-binding protein Musashi homolog 2b isoform X8

      UniProtKB/TrEMBL
      A0A8M3ASN7
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    7. XM_005157680.5 → XP_005157737.1  RNA-binding protein Musashi homolog 2b isoform X1

      See identical proteins and their annotated locations for XP_005157737.1

      UniProtKB/TrEMBL
      A0A8N7V033, Q7SXT6
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    8. XM_068213499.1 → XP_068069600.1  RNA-binding protein Musashi homolog 2b isoform X11

      UniProtKB/TrEMBL
      A0A8M2B414

    9. XM_068213498.1 → XP_068069599.1  RNA-binding protein Musashi homolog 2b isoform X10

    10. XM_068213497.1 → XP_068069598.1  RNA-binding protein Musashi homolog 2b isoform X6

    11. XM_021481364.2 → XP_021337039.1  RNA-binding protein Musashi homolog 2b isoform X12

      UniProtKB/TrEMBL
      A0A8M9QH54
      Related
      ENSDARP00000050648.8, ENSDART00000050649.10
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:23 → 97
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    12. XM_068213494.1 → XP_068069595.1  RNA-binding protein Musashi homolog 2b isoform X4

    13. XM_068213493.1 → XP_068069594.1  RNA-binding protein Musashi homolog 2b isoform X3

      UniProtKB/TrEMBL
      A0A8M2B4J9

    14. XM_021481363.2 → XP_021337038.1  RNA-binding protein Musashi homolog 2b isoform X7

      UniProtKB/TrEMBL
      A0A8M9QBW9
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:23 → 97
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    15. XM_009291629.4 → XP_009289904.1  RNA-binding protein Musashi homolog 2b isoform X2

      UniProtKB/TrEMBL
      A0A8M3AIG3
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cl17169
      Location:17 → 109
      RRM_SF; RNA recognition motif (RRM) superfamily

    16. XM_005157681.5 → XP_005157738.1  RNA-binding protein Musashi homolog 2b isoform X1

      See identical proteins and their annotated locations for XP_005157738.1

      UniProtKB/TrEMBL
      A0A8N7V033, Q7SXT6
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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