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    eef2l2 eukaryotic translation elongation factor 2, like 2 [ Danio rerio (zebrafish) ]

    Gene ID: 336168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eef2l2provided by ZNC
    Official Full Name
    eukaryotic translation elongation factor 2, like 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8112
    See related
    Ensembl:ENSDARG00000035256 AllianceGenome:ZFIN:ZDB-GENE-030131-8112
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj53d02; wu:fj53d02; si:ch211-113n10.4
    Summary
    Predicted to enable GTPase activity; ribosome binding activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to act upstream of or within translation. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Is expressed in brain and musculature system. Human ortholog(s) of this gene implicated in glaucoma; spinocerebellar ataxia type 26; and stomach cancer. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eef2l2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (41485468..41494810, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (40885124..40894701, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene AT rich interactive domain 3C (BRIGHT-like) Neighboring gene uncharacterized LOC103911098 Neighboring gene protein inhibitor of activated STAT, 2 Neighboring gene FA complementation group G Neighboring gene valosin containing protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome. Weh E, et al. PLoS One, 2017. PMID 28926587, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    elongation factor 2
    XP_021332246.1
    XP_697966.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      41485468..41494810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476571.2 → XP_021332246.1  elongation factor 2

      UniProtKB/TrEMBL
      A0A8N7UVM4, A2CE51
      Related
      ENSDARP00000051080.4, ENSDART00000051081.5
      Conserved Domains (1) summary
      PTZ00416
      Location:1 → 861
      PTZ00416; elongation factor 2; Provisional

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395242.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      253703..263078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_692874.10 → XP_697966.5  elongation factor 2

      UniProtKB/TrEMBL
      A0A8N7UVM4, A2CE51
      Conserved Domains (1) summary
      PTZ00416
      Location:1 → 861
      PTZ00416; elongation factor 2; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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