dtnbp1a dystrobrevin binding protein 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dtnbp1aprovided by ZNC
Official Full Name: dystrobrevin binding protein 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1036
See related: Ensembl:ENSDARG00000055115 AllianceGenome:ZFIN:ZDB-GENE-040426-1036
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dtnbp1; zgc:56462
Summary: Predicted to be involved in several processes, including anterograde synaptic vesicle transport; platelet dense granule organization; and regulation of synaptic vesicle exocytosis. Predicted to be located in several cellular components, including cytoplasmic vesicle membrane; endoplasmic reticulum; and postsynaptic density. Predicted to be part of BLOC-1 complex. Predicted to be active in neuron projection; plasma membrane; and synaptic vesicle membrane. Is expressed in several structures, including epidermis; neural crest; periderm; pigment cell; and retina. Used to study Hermansky-Pudlak syndrome. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 7 and schizophrenia. Orthologous to human DTNBP1 (dystrobrevin binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (25504109..25535401, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (25589071..25620398, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in anterograde synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterograde synaptic vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet dense granule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of BLOC-1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BLOC-1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in melanosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dysbindin-A

Names: BLOC-1 subunit 8-A; biogenesis of lysosome-related organelles complex 1 subunit 8-A; dystrobrevin binding protein 1; dystrobrevin-binding protein 1-A; hps7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201134.1 → NP_957428.1 dysbindin-A

See identical proteins and their annotated locations for NP_957428.1

Status: PROVISIONAL

Source sequence(s)

BC049451

UniProtKB/Swiss-Prot

Q7ZWE6

Related

ENSDARP00000071887.4, ENSDART00000077420.6

Conserved Domains (1) summary

pfam04440
Location:175 → 329

Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

25504109..25535401 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158099.5 → XP_005158156.1 dysbindin-A isoform X3

UniProtKB/TrEMBL

A0A8M2B4E5

Conserved Domains (1) summary

pfam04440
Location:174 → 328

Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
XM_005158098.5 → XP_005158155.1 dysbindin-A isoform X2

UniProtKB/TrEMBL

A0A8M2B4X1

Conserved Domains (1) summary

pfam04440
Location:174 → 329

Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
XM_005158101.4 → XP_005158158.1 dysbindin-A isoform X5

UniProtKB/TrEMBL

A0A8M2B4E8

Conserved Domains (2) summary

pfam04440
Location:175 → 326

Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

pfam07851
Location:118 → 211

TMPIT; TMPIT-like protein
XM_005158100.4 → XP_005158157.1 dysbindin-A isoform X4

UniProtKB/TrEMBL

A0A8M2B4E2

Conserved Domains (2) summary

pfam04440
Location:175 → 327

Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

pfam07851
Location:118 → 211

TMPIT; TMPIT-like protein
XM_005158097.4 → XP_005158154.1 dysbindin-A isoform X1

UniProtKB/TrEMBL

A0A8M2B510

Conserved Domains (1) summary

pfam04440
Location:175 → 330

Dysbindin; Dysbindin (Dystrobrevin binding protein 1)