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    npsn nephrosin [ Danio rerio (zebrafish) ]

    Gene ID: 404039, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npsnprovided by ZNC
    Official Full Name
    nephrosinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040420-2
    See related
    Ensembl:ENSDARG00000010423 AllianceGenome:ZFIN:ZDB-GENE-040420-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    npsnl; zgc:110470; zgc:152831
    Summary
    Predicted to enable metalloendopeptidase activity. Acts upstream of or within defense response to bacterium. Is expressed in hematopoietic cell and hematopoietic system. Orthologous to human ASTL (astacin like metalloendopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See npsn in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (38653481..38658412, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (38382223..38387154, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene six-cysteine containing astacin protease 4 Neighboring gene six-cysteine containing astacin protease 3 Neighboring gene six-cysteine containing astacin protease 1 Neighboring gene mitochondrial carrier homolog 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb. Huang Z, et al. J Biol Chem, 2021 Jan-Jun. PMID 33434583, Free PMC Article
    2. Zebrafish nephrosin helps host defence against Escherichia coli infection. Di Q, et al. Open Biol, 2017 Aug. PMID 28835569, Free PMC Article
    3. In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury. Zhang Y, et al. J Immunol, 2008 Aug 1. PMID 18641354
    4. Myeloperoxidase-deficient zebrafish show an augmented inflammatory response to challenge with Candida albicans. Wang K, et al. Fish Shellfish Immunol, 2015 May. PMID 25665803
    5. Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. Dong ZW, et al. J Hematol Oncol, 2014 Mar 5. PMID 24598081, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC152831, MGC158184

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    nephrosin
    Names
    ZC6AST2
    NP_001071247.1
    NP_991319.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077779.2 → NP_001071247.1  nephrosin isoform 1 precursor

      See identical proteins and their annotated locations for NP_001071247.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BX957297, EH434994
      UniProtKB/TrEMBL
      A0A8N7UYF3, Q05AP0
      Related
      ENSDARP00000012180.5, ENSDART00000017155.8
      Conserved Domains (2) summary
      cd04283
      Location:93 → 273
      ZnMc_hatching_enzyme; Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted by teleost embryos to digest the egg envelope or chorion. In some teleosts, the hatching enzyme may be a system consisting of two evolutionary related ...
      pfam01400
      Location:87 → 272
      Astacin; Astacin (Peptidase family M12A)

    2. NM_205756.3 → NP_991319.2  nephrosin isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the 3' terminal exon and extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BX957297
      UniProtKB/TrEMBL
      A0A8M1PHD0, F1REP3
      Related
      ENSDARP00000100461.2, ENSDART00000109463.5
      Conserved Domains (2) summary
      cd04283
      Location:93 → 273
      ZnMc_hatching_enzyme; Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted by teleost embryos to digest the egg envelope or chorion. In some teleosts, the hatching enzyme may be a system consisting of two evolutionary related ...
      pfam01400
      Location:87 → 275
      Astacin; Astacin (Peptidase family M12A)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      38653481..38658412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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