h2ax H2A.X variant histone [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: h2axprovided by ZNC
Official Full Name: H2A.X variant histoneprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-987
See related: Ensembl:ENSDARG00000029406 AllianceGenome:ZFIN:ZDB-GENE-040426-987
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: h2afx; zgc:56329
Summary: Predicted to be a structural constituent of chromatin. Acts upstream of or within DNA damage response. Predicted to be located in centrosome and chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. Is expressed in several structures, including brain; oocyte; proliferative region; sensory system; and unfertilized egg. Orthologous to human H2AX (H2A.X variant histone). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (30534702..30535318, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (29934549..29935165, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results firstly demonstrate the antibacterial property of the complete histone H2A against gram-negative bacteria E. piscicida in vivo and the correlation between zebrafish histone H2A and RIP2 adaptor protein on the transcriptional regulation of antibacterial genes and MHC related genes.
Title: Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone H2AX

Names: H2A histone family, member X; H2A.X; H2a/x; histone H2A.x

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201073.1 → NP_957367.1 histone H2AX

See identical proteins and their annotated locations for NP_957367.1

Status: PROVISIONAL

Source sequence(s)

BC046078

UniProtKB/Swiss-Prot

Q7ZUY3

UniProtKB/TrEMBL

A6QL59

Related

ENSDARP00000040327.2, ENSDART00000040328.4

Conserved Domains (2) summary

PTZ00017
Location:1 → 121

PTZ00017; histone H2A; Provisional

cd00074
Location:6 → 120

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...