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    apoda.2 apolipoprotein Da, duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 100148022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    apoda.2provided by ZNC
    Official Full Name
    apolipoprotein Da, duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-551
    See related
    Ensembl:ENSDARG00000060350 AllianceGenome:ZFIN:ZDB-GENE-070912-551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-52k20.7
    Summary
    Predicted to enable lipid binding activity. Predicted to be involved in lipid metabolic process and response to reactive oxygen species. Predicted to act upstream of or within brain development; lipid transport; and tissue regeneration. Predicted to be located in extracellular region. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human APOD (apolipoprotein D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See apoda.2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37207462..37215987)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37225005..37233530)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 19 Neighboring gene COPI coat complex subunit alpha Neighboring gene apolipoprotein Da, duplicate 1 Neighboring gene sterile alpha motif domain containing 7 Neighboring gene SEC62 homolog, preprotein translocation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pathway-specific protein domains are predictive for human diseases. Shim JE, et al. PLoS Comput Biol, 2019 May. PMID 31075101, Free PMC Article
    2. Transcriptional signature of accessory cells in the lateral line, using the Tnk1bp1:EGFP transgenic zebrafish line. Behra M, et al. BMC Dev Biol, 2012 Jan 24. PMID 22273551, Free PMC Article
    3. Knockout of zebrafish colony-stimulating factor 1 receptor by CRISPR/Cas9 affects metabolism and locomotion capacity. Meng H, et al. Biochem Biophys Res Commun, 2021 Apr 30. PMID 33725575
    4. An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. Mohseny AB, et al. J Pathol, 2012 Jun. PMID 22297719
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to reactive oxygen species IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    apolipoprotein Da, duplicate 2
    Names
    apolipoprotein D-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201348.1 → NP_001188277.1  apolipoprotein Da, duplicate 2 precursor

      See identical proteins and their annotated locations for NP_001188277.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      DY569710, EH539771, EH543264
      UniProtKB/TrEMBL
      A0A8M1P3E0, E7F2R8
      Related
      ENSDARP00000113343.1, ENSDART00000138952.3
      Conserved Domains (1) summary
      cl21528
      Location:36 → 180
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    2. NM_001201349.1 → NP_001188278.1  apolipoprotein Da, duplicate 2 precursor

      See identical proteins and their annotated locations for NP_001188278.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      DY569710, EH543264
      UniProtKB/TrEMBL
      A0A8M1P3E0, E7F2R8
      Related
      ENSDARP00000117077.1, ENSDART00000132856.3
      Conserved Domains (1) summary
      cl21528
      Location:36 → 180
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    3. NM_001201350.1 → NP_001188279.1  apolipoprotein Da, duplicate 2 precursor

      See identical proteins and their annotated locations for NP_001188279.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      DY569710, EH539771, EH543264
      UniProtKB/TrEMBL
      A0A8M1P3E0, E7F2R8
      Related
      ENSDARP00000123418.1, ENSDART00000143468.2
      Conserved Domains (1) summary
      cl21528
      Location:36 → 180
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    4. NM_001201351.1 → NP_001188280.1  apolipoprotein Da, duplicate 2 precursor

      See identical proteins and their annotated locations for NP_001188280.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      DY569710, EH505051, EH543264
      UniProtKB/TrEMBL
      A0A8M1P3E0, E7F2R8
      Related
      ENSDARP00000123122.1, ENSDART00000137272.3
      Conserved Domains (1) summary
      cl21528
      Location:36 → 180
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      37207462..37215987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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