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    cep135 centrosomal protein 135 [ Danio rerio (zebrafish) ]

    Gene ID: 553303, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cep135provided by ZNC
    Official Full Name
    centrosomal protein 135provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041210-325
    See related
    Ensembl:ENSDARG00000002991 AllianceGenome:ZFIN:ZDB-GENE-041210-325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkeyp-117h8.1
    Summary
    Predicted to be located in centriole. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 8. Orthologous to human CEP135 (centrosomal protein 135). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cep135 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (25711718..25735315)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (25812295..25836225)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene capping protein inhibiting regulator of actin dynamics Neighboring gene carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 Neighboring gene transfer RNA cysteine (anticodon GCA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring. Blanc M, et al. Sci Total Environ, 2021 Feb 1. PMID 32911150
    2. Genomic responses of DNA methylation and transcript profiles in zebrafish cells upon nutrient deprivation stress. Fan X, et al. Sci Total Environ, 2020 Jun 20. PMID 32208287
    3. Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. Sanchez NE, et al. G3 (Bethesda), 2017 Oct 5. PMID 28855284, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 135 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199990.1 → NP_001186919.1  centrosomal protein of 135 kDa

      See identical proteins and their annotated locations for NP_001186919.1

      Status: VALIDATED

      Source sequence(s)
      BX294157, CR352243
      UniProtKB/Swiss-Prot
      Q5RG45
      Related
      ENSDARP00000035272.7, ENSDART00000033436.9
      Conserved Domains (2) summary
      TIGR02168
      Location:202 → 963
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15290
      Location:291 → 407
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      25711718..25735315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160572.5 → XP_005160629.1  centrosomal protein of 135 kDa isoform X1

      See identical proteins and their annotated locations for XP_005160629.1

      UniProtKB/TrEMBL
      A0A8M2B7F9, F1R3P9
      Conserved Domains (2) summary
      TIGR02168
      Location:202 → 963
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15290
      Location:291 → 407
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    2. XM_005160573.5 → XP_005160630.1  centrosomal protein of 135 kDa isoform X1

      See identical proteins and their annotated locations for XP_005160630.1

      UniProtKB/TrEMBL
      A0A8M2B7F9, F1R3P9
      Conserved Domains (2) summary
      TIGR02168
      Location:202 → 963
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15290
      Location:291 → 407
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    3. XM_005160571.5 → XP_005160628.1  centrosomal protein of 135 kDa isoform X1

      See identical proteins and their annotated locations for XP_005160628.1

      UniProtKB/TrEMBL
      A0A8M2B7F9, F1R3P9
      Related
      ENSDARP00000107420.1, ENSDART00000121585.4
      Conserved Domains (2) summary
      TIGR02168
      Location:202 → 963
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15290
      Location:291 → 407
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    4. XM_009300714.4 → XP_009298989.1  centrosomal protein of 135 kDa isoform X2

      See identical proteins and their annotated locations for XP_009298989.1

      UniProtKB/Swiss-Prot
      Q5RG45
      Conserved Domains (2) summary
      TIGR02168
      Location:202 → 963
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15290
      Location:291 → 407
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RG45.2 GenPept UniProtKB/Swiss-Prot:Q5RG45

    Gene LinkOut

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