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    spring1 SREBF pathway regulator in golgi 1 [ Danio rerio (zebrafish) ]

    Gene ID: 553772, updated on 4-Jan-2025

    Summary

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    Official Symbol
    spring1provided by ZNC
    Official Full Name
    SREBF pathway regulator in golgi 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-367
    See related
    Ensembl:ENSDARG00000078315 AllianceGenome:ZFIN:ZDB-GENE-050522-367
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    spring; zgc:110063
    Summary
    Predicted to be involved in positive regulation of SREBP signaling pathway. Predicted to be located in Golgi membrane. Orthologous to human SPRING1 (SREBF pathway regulator in golgi 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See spring1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (11944262..11960215)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (11444045..11459998)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene F-box protein 21 Neighboring gene tescalcin a Neighboring gene F-box and WD repeat domain containing 8 Neighboring gene ring finger protein, transmembrane 2 Neighboring gene oncostatin M Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism. Bayraktar EC, et al. Nat Metab, 2020 Jun. PMID 32694732, Free PMC Article
    2. Oncostatin M and Kit-Ligand Control Hematopoietic Stem Cell Fate during Zebrafish Embryogenesis. Mahony CB, et al. Stem Cell Reports, 2018 Jun 5. PMID 29779898, Free PMC Article
    3. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Trinh le A, et al. Genes Dev, 2011 Nov 1. PMID 22056673, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC110063

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of SREBP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of SREBP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SREBP regulating gene protein
    Names
    UPF0454 protein C12orf49 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020737.1 → NP_001018573.1  SREBP regulating gene protein

      See identical proteins and their annotated locations for NP_001018573.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095168
      UniProtKB/Swiss-Prot
      Q503V3
      Related
      ENSDARP00000100969.2, ENSDART00000114873.4
      Conserved Domains (2) summary
      pfam10218
      Location:67 → 189
      DUF2054; Uncharacterized conserved protein (DUF2054)
      cl23724
      Location:2 → 80
      PHP; Polymerase and Histidinol Phosphatase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      11944262..11960215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165044.1 → XP_005165101.1  SREBP regulating gene protein isoform X1

      UniProtKB/TrEMBL
      A0A8M2BC96
      Conserved Domains (1) summary
      pfam10218
      Location:38 → 160
      DUF2054; Uncharacterized conserved protein (DUF2054)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q503V3.1 GenPept UniProtKB/Swiss-Prot:Q503V3

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