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    numa1 nuclear mitotic apparatus protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 572344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    numa1provided by ZNC
    Official Full Name
    nuclear mitotic apparatus protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110517-1
    See related
    Ensembl:ENSDARG00000102483 AllianceGenome:ZFIN:ZDB-GENE-110517-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    NuMA; fb44b02; wu:fb44b02
    Summary
    Located in cell cortex and spindle. Is expressed in blastodisc and epiblast. Orthologous to human NUMA1 (nuclear mitotic apparatus protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See numa1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (44021044..44052928, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (43997675..44029482, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene NLR family, CARD domain containing 3-like Neighboring gene nuclear mitotic apparatus protein 1-like Neighboring gene small Cajal body-specific RNA 14 Neighboring gene leucine rich repeat containing 51 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish. Ségalen M, et al. Dev Cell, 2010 Nov 16. PMID 21074723, Free PMC Article
    2. The splicing factor DHX38 enables retinal development through safeguarding genome integrity. Sun K, et al. iScience, 2023 Nov 17. PMID 37867960, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear mitotic apparatus protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329981.1 → NP_001316910.1  nuclear mitotic apparatus protein 1

      Status: VALIDATED

      Source sequence(s)
      CU655961, FO704909
      UniProtKB/TrEMBL
      A0A0R4IH76, A0A8M1P5E1
      Related
      ENSDARP00000132708.1, ENSDART00000166209.2
      Conserved Domains (3) summary
      pfam05483
      Location:176 → 919
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      pfam01576
      Location:840 → 1772
      Myosin_tail_1; Myosin tail
      pfam14988
      Location:1707 → 1913
      DUF4515; Domain of unknown function (DUF4515)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      44021044..44052928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291966.4 → XP_009290241.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_009290241.1

      UniProtKB/TrEMBL
      A0A8M3B1D5
      Conserved Domains (3) summary
      pfam05483
      Location:176 → 919
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      pfam01576
      Location:840 → 1772
      Myosin_tail_1; Myosin tail
      pfam14988
      Location:1707 → 1913
      DUF4515; Domain of unknown function (DUF4515)
    Nucleotide Protein Strain
    Heading Accession and Version

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