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    pvalb7 parvalbumin 7 [ Danio rerio (zebrafish) ]

    Gene ID: 402807, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pvalb7provided by ZNC
    Official Full Name
    parvalbumin 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-285
    See related
    Ensembl:ENSDARG00000034705 AllianceGenome:ZFIN:ZDB-GENE-040718-285
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pvalb; zgc:92782
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be active in cytoplasm. Is expressed in central nervous system; midbrain interneuron; musculature system; and somite. Orthologous to human PVALB (parvalbumin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pvalb7 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (29168691..29242347, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (29219499..29293152, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group VI (cytosolic, calcium-independent) Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2b Neighboring gene neutrophil cytosolic factor 4 Neighboring gene platelet-derived growth factor beta polypeptide a Neighboring gene adrenoceptor alpha 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of parvalbumin isotypes from grass carp (Ctenopharyngodon idella). Li Z, et al. J Agric Food Chem, 2014 Jul 2. PMID 24866418
    2. Combinatorial analysis of calcium-binding proteins in larval and adult zebrafish primary olfactory system identifies differential olfactory bulb glomerular projection fields. Kress S, et al. Brain Struct Funct, 2015 Jul. PMID 24728871
    3. Mutations in the RNA exosome component gene EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration. Wan J, et al. Nat Genet, 2012 Apr 29. PMID 22544365, Free PMC Article
    4. A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease. Kyöstilä K, et al. PLoS Genet, 2015 Apr. PMID 25875846, Free PMC Article
    5. Roles of carbonic anhydrase 8 in neuronal cells and zebrafish. Huang MS, et al. Biochim Biophys Acta, 2014 Sep. PMID 24794067

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrated that One singular glomerulus (mdG2) exhibits S100 and parvalbumin-positive fibers, apparently originating from all crypt cells plus some microvillous olfactory sensory neuronss.
      Title: Combinatorial analysis of calcium-binding proteins in larval and adult zebrafish primary olfactory system identifies differential olfactory bulb glomerular projection fields.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    parvalbumin-7
    Names
    parvalbumin alpha
    parvalbumin-4a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205574.2 → NP_991137.2  parvalbumin-7

      See identical proteins and their annotated locations for NP_991137.2

      Status: PROVISIONAL

      Source sequence(s)
      BC076256
      UniProtKB/Swiss-Prot
      Q6DGT3, Q804W2
      UniProtKB/TrEMBL
      Q1LWD7
      Related
      ENSDARP00000040760.5, ENSDART00000040761.7
      Conserved Domains (2) summary
      cd00051
      Location:44 → 103
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:44 → 107
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      29168691..29242347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161792.3 → XP_005161849.1  parvalbumin-7 isoform X1

      See identical proteins and their annotated locations for XP_005161849.1

      UniProtKB/Swiss-Prot
      Q6DGT3, Q804W2
      UniProtKB/TrEMBL
      Q1LWD7
      Related
      ENSDARP00000122628.1, ENSDART00000132702.2
      Conserved Domains (2) summary
      cd00051
      Location:44 → 103
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:44 → 107
      EF-hand_7; EF-hand domain pair

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395117.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      138227..208964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q804W2.3 GenPept UniProtKB/Swiss-Prot:Q804W2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.