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    cdk11b cyclin dependent kinase 11B [ Danio rerio (zebrafish) ]

    Gene ID: 494103, updated on 9-Dec-2024

    Summary

    Official Symbol
    cdk11bprovided by ZNC
    Official Full Name
    cyclin dependent kinase 11Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-74
    See related
    Ensembl:ENSDARG00000102546 AllianceGenome:ZFIN:ZDB-GENE-041212-74
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cdc2l1; im:7142267; zgc:101589
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within smoothened signaling pathway. Predicted to be active in nucleus. Orthologous to several human genes including CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See cdk11b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (53948192..53960349, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (53615204..53627412, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene matrix metallopeptidase 23ba Neighboring gene si:ch73-236j9.2 Neighboring gene solute carrier family 35 member E2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding  
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables kinase activity  
    enables protein kinase activity  
    enables protein serine/threonine kinase activity  
    enables transferase activity  

    General protein information

    Preferred Names
    cyclin-dependent kinase 11B
    Names
    cell division cycle 2-like 1 (PITSLRE proteins)
    NP_001008646.1
    XP_009302607.1
    XP_009302610.1
    XP_068079035.1
    XP_068079036.1
    XP_068079037.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008646.1 → NP_001008646.1  cyclin-dependent kinase 11B

      See identical proteins and their annotated locations for NP_001008646.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086709
      UniProtKB/TrEMBL
      Q5PRD1
      Related
      ENSDARP00000138340.1, ENSDART00000160074.2
      Conserved Domains (2) summary
      cd07843
      Location:437 → 728
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:440 → 730
      PLN00009; cyclin-dependent kinase A; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      53948192..53960349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222936.1 → XP_068079037.1  cyclin-dependent kinase 11B isoform X5

    2. XM_009304335.4 → XP_009302610.1  cyclin-dependent kinase 11B isoform X4

      UniProtKB/TrEMBL
      A0A8M3AVM5
      Conserved Domains (2) summary
      cd07843
      Location:387 → 678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:390 → 680
      PLN00009; cyclin-dependent kinase A; Provisional
    3. XM_068222935.1 → XP_068079036.1  cyclin-dependent kinase 11B isoform X3

    4. XM_068222934.1 → XP_068079035.1  cyclin-dependent kinase 11B isoform X2

    5. XM_009304332.4 → XP_009302607.1  cyclin-dependent kinase 11B isoform X1

      UniProtKB/TrEMBL
      A0A8M3BC62
      Conserved Domains (2) summary
      cd07843
      Location:444 → 735
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:447 → 737
      PLN00009; cyclin-dependent kinase A; Provisional
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