guca1c guanylate cyclase activator 1C [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: guca1cprovided by ZNC
Official Full Name: guanylate cyclase activator 1Cprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030829-1
See related: Ensembl:ENSDARG00000030758 AllianceGenome:ZFIN:ZDB-GENE-030829-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gcap3
Summary: Enables calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Predicted to be involved in regulation of signal transduction. Is expressed in cranial nerve II and eye. Orthologous to human GUCA1C (guanylate cyclase activator 1C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (2888419..2903626, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (2925136..2940343, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of GUCA1C in Primary Congenital Glaucoma and in the Retina: Functional Evaluation in Zebrafish.
Title: Role of GUCA1C in Primary Congenital Glaucoma and in the Retina: Functional Evaluation in Zebrafish.
Examination of larval and adult stages of the developing zebrafish retina indicates that GCAP3 is first expressed in a non-myristoylated form, but is finally present in the adult retina as a myristoylated protein.
Title: Operation profile of zebrafish guanylate cyclase-activating protein 3.
Data show that high guanylate cyclase activities in larval eye preparations and the precisely controlled coexpression of guanylate cyclases and GCAPs 3, 4, and 7 coincide with the onset of visual function at 3-4 days post fertilization.
Title: Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calcium sensitive guanylate cyclase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium sensitive guanylate cyclase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanylyl cyclase-activating protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194393.2 → NP_919374.1 guanylyl cyclase-activating protein 3

See identical proteins and their annotated locations for NP_919374.1

Status: VALIDATED

Source sequence(s)

EH435208, EH436602, EH459931

UniProtKB/TrEMBL

F6P7E5, Q789R8, Q8UUX9

Related

ENSDARP00000043225.4, ENSDART00000043226.7

Conserved Domains (2) summary

COG5126
Location:6 → 162

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:89 → 157

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...