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    dcdc2b doublecortin domain containing 2B [ Danio rerio (zebrafish) ]

    Gene ID: 563259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dcdc2bprovided by ZNC
    Official Full Name
    doublecortin domain containing 2Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051113-124
    See related
    Ensembl:ENSDARG00000053744 AllianceGenome:ZFIN:ZDB-GENE-051113-124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:123267
    Summary
    Acts upstream of or within several processes, including neuromast hair cell development; otolith morphogenesis; and sensory perception of sound. Predicted to be active in microtubule and microtubule organizing center. Is expressed in otic vesicle. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autosomal recessive nonsyndromic deafness 66; dyslexia; nephronophthisis 19; and sclerosing cholangitis. Orthologous to several human genes including DCDC2B (doublecortin domain containing 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dcdc2b in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (33304193..33314758)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (33171560..33184306)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 28B Neighboring gene IQ motif containing C Neighboring gene si:dkey-71p21.13 Neighboring gene transmembrane protein 234 Neighboring gene uncharacterized LOC110440192

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2. Bieder A, et al. BMC Mol Cell Biol, 2023 May 26. PMID 37237337, Free PMC Article
    2. A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation. Grati M, et al. Hum Mol Genet, 2015 May 1. PMID 25601850, Free PMC Article
    3. DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling. Schueler M, et al. Am J Hum Genet, 2015 Jan 8. PMID 25557784, Free PMC Article
    4. Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation. Shu T, et al. Gen Comp Endocrinol, 2020 Sep 1. PMID 32283058
    5. Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. Lam SH, et al. BMC Med Genomics, 2011 May 16. PMID 21575170, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2.
      Title: Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123267

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuromast hair cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within otolith morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    doublecortin domain-containing protein 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037689.2 → NP_001032778.2  doublecortin domain-containing protein 2B

      Status: VALIDATED

      Source sequence(s)
      BX284673
      UniProtKB/TrEMBL
      A0A8M6Z9L0, B8A4M4
      Related
      ENSDARP00000070307.3, ENSDART00000075826.5
      Conserved Domains (2) summary
      cd01617
      Location:14 → 92
      DCX; Ubiquitin-like domain of DCX
      cl00155
      Location:129 → 207
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      33304193..33314758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480609.2 → XP_021336284.1  doublecortin domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z1P8
      Conserved Domains (2) summary
      cd01617
      Location:14 → 92
      DCX; Ubiquitin-like domain of DCX
      cl00155
      Location:129 → 207
      UBQ; Ubiquitin-like proteins

    2. XM_017358763.3 → XP_017214252.1  doublecortin domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z9L0, B8A4M4
      Conserved Domains (2) summary
      cd01617
      Location:14 → 92
      DCX; Ubiquitin-like domain of DCX
      cl00155
      Location:129 → 207
      UBQ; Ubiquitin-like proteins

    3. XM_017358760.3 → XP_017214249.1  doublecortin domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z1P8
      Conserved Domains (2) summary
      cd01617
      Location:14 → 92
      DCX; Ubiquitin-like domain of DCX
      cl00155
      Location:129 → 207
      UBQ; Ubiquitin-like proteins

    4. XM_017358762.3 → XP_017214251.1  doublecortin domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z1P8
      Conserved Domains (2) summary
      cd01617
      Location:14 → 92
      DCX; Ubiquitin-like domain of DCX
      cl00155
      Location:129 → 207
      UBQ; Ubiquitin-like proteins

    5. XM_017358765.3 → XP_017214254.1  doublecortin domain-containing protein 2B isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z961
    Nucleotide Protein
    Heading Accession and Version

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