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    zzef1 zinc finger, ZZ-type with EF hand domain 1 [ Danio rerio (zebrafish) ]

    Gene ID: 566682, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zzef1provided by ZNC
    Official Full Name
    zinc finger, ZZ-type with EF hand domain 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041222-2
    See related
    Ensembl:ENSDARG00000094380 AllianceGenome:ZFIN:ZDB-GENE-041222-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-7b17.3
    Summary
    Predicted to enable calcium ion binding activity and zinc ion binding activity. Predicted to be involved in anatomical structure morphogenesis. Orthologous to human ZZEF1 (zinc finger ZZ-type and EF-hand domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See zzef1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    54
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (31036922..31109972)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (30436566..30509819)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and FYVE domain containing 1 Neighboring gene cytochrome b5 domain containing 2 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1, alpha a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger ZZ-type and EF-hand domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      31036922..31109972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301579.4 → XP_009299854.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IX34, A0A8M9P8V5
      Related
      ENSDARP00000141398.1, ENSDART00000162121.3
      Conserved Domains (5) summary
      cd02249
      Location:1886 → 1933
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cd02343
      Location:1837 → 1884
      ZZ_EF; Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      cl00049
      Location:1142 → 1234
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl02148
      Location:288 → 418
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl25352
      Location:114 → 176
      EFh_PEF; The penta-EF hand (PEF) family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394583.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      318391..355827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471612.2 → XP_021327287.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0R4IX34, A0A8M9P8V5
      Conserved Domains (5) summary
      cd02249
      Location:1886 → 1933
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cd02343
      Location:1837 → 1884
      ZZ_EF; Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      cl00049
      Location:1142 → 1234
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl02148
      Location:288 → 418
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl25352
      Location:114 → 176
      EFh_PEF; The penta-EF hand (PEF) family
    Nucleotide Protein Strain
    Heading Accession and Version

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