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    si:ch211-137a8.2 si:ch211-137a8.2 [ Danio rerio (zebrafish) ]

    Gene ID: 777613, updated on 9-Dec-2024

    Summary

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    Official Symbol
    si:ch211-137a8.2provided by ZNC
    Official Full Name
    si:ch211-137a8.2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061103-172
    See related
    Ensembl:ENSDARG00000068926 AllianceGenome:ZFIN:ZDB-GENE-061103-172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:152987
    Summary
    Predicted to be located in membrane and nuclear envelope. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 76. Orthologous to human SYNE4 (spectrin repeat containing nuclear envelope family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See si:ch211-137a8.2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (29024922..29071870)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (29092046..29138994)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene CAP-GLY domain containing linker protein 3 Neighboring gene dharma Neighboring gene si:ch211-137a8.4 Neighboring gene zgc:162698

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish. Ezhkova D, et al. Biol Open, 2023 Jun 15. PMID 37272628, Free PMC Article
    2. Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Zeng S, et al. Gene, 2002 Jul 10. PMID 12234666
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    part_of meiotic nuclear membrane microtubule tethering complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC777613

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328091.1 → NP_001315020.1  uncharacterized protein LOC777613

      Status: VALIDATED

      Source sequence(s)
      BX004776, EH541040, EH557057, EH562188, EH578152
      UniProtKB/TrEMBL
      A0A8M3B132, F1Q5Y7
      Related
      ENSDARP00000118645.1, ENSDART00000144126.3
      Conserved Domains (2) summary
      cd00176
      Location:98 → 308
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:597 → 632
      KASH; Nuclear envelope localization domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      29024922..29071870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213588.1 → XP_068069689.1  uncharacterized protein LOC777613 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B132, F1Q5Y7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077721.1: Suppressed sequence

      Description
      NM_001077721.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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